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Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn

OBJECTIVES: A novel catheter that can measure mucosal admittance (MA), the inverse of impedance, was developed recently. In this pilot study, we aimed to clarify the usefulness of measuring MA for diagnosing gastroesophageal reflux disease (GERD). METHODS: We conducted two prospective studies. In th...

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Autores principales: Matsumura, Tomoaki, Ishigami, Hideaki, Fujie, Mai, Taida, Takashi, Kasamatsu, Shingo, Okimoto, Kenichiro, Saito, Keiko, Maruoka, Daisuke, Nakagawa, Tomoo, Suzuki, Takeshi, Katsuno, Tatsuro, Arai, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518945/
https://www.ncbi.nlm.nih.gov/pubmed/28569739
http://dx.doi.org/10.1038/ctg.2017.22
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author Matsumura, Tomoaki
Ishigami, Hideaki
Fujie, Mai
Taida, Takashi
Kasamatsu, Shingo
Okimoto, Kenichiro
Saito, Keiko
Maruoka, Daisuke
Nakagawa, Tomoo
Suzuki, Takeshi
Katsuno, Tatsuro
Arai, Makoto
author_facet Matsumura, Tomoaki
Ishigami, Hideaki
Fujie, Mai
Taida, Takashi
Kasamatsu, Shingo
Okimoto, Kenichiro
Saito, Keiko
Maruoka, Daisuke
Nakagawa, Tomoo
Suzuki, Takeshi
Katsuno, Tatsuro
Arai, Makoto
author_sort Matsumura, Tomoaki
collection PubMed
description OBJECTIVES: A novel catheter that can measure mucosal admittance (MA), the inverse of impedance, was developed recently. In this pilot study, we aimed to clarify the usefulness of measuring MA for diagnosing gastroesophageal reflux disease (GERD). METHODS: We conducted two prospective studies. In the first study, esophageal MA was evaluated in 120 participants (24 with erosive esophagitis, 82 with heartburn but non-erosive esophagitis, and 14 healthy volunteers) and compared with the endoscopic findings. In the second study, multichannel intraluminal impedance combined with pH (MII-pH) tests was conducted followed by an MA measurement in 33 patients with non-erosive esophagitis and proton pump inhibitor (PPI)-refractory heartburn. Based on the MII-pH test results, patients were divided into GERD or functional heartburn (FH). MA was compared between the GERD and FH groups and also compared with the baseline impedance (BI) and acid exposure time (AET). RESULTS: Median MA at the distal esophagus was significantly higher in patients with erosive esophagitis compared with that in patients with non-erosive esophagitis and healthy volunteers (46.8, 13.1 and 6.5, respectively, P<0.01). In patients with PPI-refractory heartburn, the median MA at the distal esophagus was significantly higher in patients with GERD than those with FH (19.3 vs. 7.2, P<0.05). There was a negative correlation between MA and BI, and a positive correlation between MA and AET at the distal esophagus (r=−0.46 and r=0.53, P<0.05). CONCLUSIONS: Real-time measurement of MA is useful to distinguish GERD from non-GERD.
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spelling pubmed-55189452017-07-24 Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn Matsumura, Tomoaki Ishigami, Hideaki Fujie, Mai Taida, Takashi Kasamatsu, Shingo Okimoto, Kenichiro Saito, Keiko Maruoka, Daisuke Nakagawa, Tomoo Suzuki, Takeshi Katsuno, Tatsuro Arai, Makoto Clin Transl Gastroenterol Original Communication OBJECTIVES: A novel catheter that can measure mucosal admittance (MA), the inverse of impedance, was developed recently. In this pilot study, we aimed to clarify the usefulness of measuring MA for diagnosing gastroesophageal reflux disease (GERD). METHODS: We conducted two prospective studies. In the first study, esophageal MA was evaluated in 120 participants (24 with erosive esophagitis, 82 with heartburn but non-erosive esophagitis, and 14 healthy volunteers) and compared with the endoscopic findings. In the second study, multichannel intraluminal impedance combined with pH (MII-pH) tests was conducted followed by an MA measurement in 33 patients with non-erosive esophagitis and proton pump inhibitor (PPI)-refractory heartburn. Based on the MII-pH test results, patients were divided into GERD or functional heartburn (FH). MA was compared between the GERD and FH groups and also compared with the baseline impedance (BI) and acid exposure time (AET). RESULTS: Median MA at the distal esophagus was significantly higher in patients with erosive esophagitis compared with that in patients with non-erosive esophagitis and healthy volunteers (46.8, 13.1 and 6.5, respectively, P<0.01). In patients with PPI-refractory heartburn, the median MA at the distal esophagus was significantly higher in patients with GERD than those with FH (19.3 vs. 7.2, P<0.05). There was a negative correlation between MA and BI, and a positive correlation between MA and AET at the distal esophagus (r=−0.46 and r=0.53, P<0.05). CONCLUSIONS: Real-time measurement of MA is useful to distinguish GERD from non-GERD. Nature Publishing Group 2017-06 2017-06-01 /pmc/articles/PMC5518945/ /pubmed/28569739 http://dx.doi.org/10.1038/ctg.2017.22 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-sa/4.0/ Clinical and Translational Gastroenterology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Original Communication
Matsumura, Tomoaki
Ishigami, Hideaki
Fujie, Mai
Taida, Takashi
Kasamatsu, Shingo
Okimoto, Kenichiro
Saito, Keiko
Maruoka, Daisuke
Nakagawa, Tomoo
Suzuki, Takeshi
Katsuno, Tatsuro
Arai, Makoto
Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn
title Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn
title_full Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn
title_fullStr Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn
title_full_unstemmed Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn
title_short Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn
title_sort endoscopic-guided measurement of mucosal admittance can discriminate gastroesophageal reflux disease from functional heartburn
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518945/
https://www.ncbi.nlm.nih.gov/pubmed/28569739
http://dx.doi.org/10.1038/ctg.2017.22
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