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Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD(+) AML cell growth

Acute myelogenous leukemia (AML) is often associated with activating mutations in the receptor tyrosine kinase, Flt3, including internal tandem duplications (ITDs) within the regulatory juxtamembrane region. Previous studies have linked Flt3-ITD to the activation of the Fes protein tyrosine kinase i...

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Detalles Bibliográficos
Autores principales:	Weir, Mark C., Hellwig, Sabine, Tan, Li, Liu, Yao, Gray, Nathanael S., Smithgall, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519068/ https://www.ncbi.nlm.nih.gov/pubmed/28727840 http://dx.doi.org/10.1371/journal.pone.0181178

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