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Frizzled are colonic epithelial receptors for Clostridium difficile toxin B

Clostridium difficile toxin B (TcdB) is a critical virulence factor causing diseases associated with C. difficile infection (CDI). Here we carried out CRISPR/Cas9-mediated genome-wide screens and identified the members of the Wnt receptor Frizzled (FZDs) family as TcdB receptors. TcdB binds to the c...

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Detalles Bibliográficos
Autores principales:	Tao, Liang, Zhang, Jie, Meraner, Paul, Tovaglieri, Alessio, Wu, Xiaoqian, Gerhard, Ralf, Zhang, Xinjun, Stallcup, William B., Miao, Ji, He, Xi, Hurdle, Julian G., Breault, David T., Brass, Abraham L., Dong, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519134/ https://www.ncbi.nlm.nih.gov/pubmed/27680706 http://dx.doi.org/10.1038/nature19799

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