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Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans

OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associat...

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Autores principales: Larifla, Laurent, Armand, Christophe, Bangou, Jacqueline, Blanchet-Deverly, Anne, Numeric, Patrick, Fonteau, Christiane, Michel, Carl-Thony, Ferdinand, Séverine, Bourrhis, Véronique, Vélayoudom-Céphise, Fritz-Line
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519172/
https://www.ncbi.nlm.nih.gov/pubmed/28727855
http://dx.doi.org/10.1371/journal.pone.0181620
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author Larifla, Laurent
Armand, Christophe
Bangou, Jacqueline
Blanchet-Deverly, Anne
Numeric, Patrick
Fonteau, Christiane
Michel, Carl-Thony
Ferdinand, Séverine
Bourrhis, Véronique
Vélayoudom-Céphise, Fritz-Line
author_facet Larifla, Laurent
Armand, Christophe
Bangou, Jacqueline
Blanchet-Deverly, Anne
Numeric, Patrick
Fonteau, Christiane
Michel, Carl-Thony
Ferdinand, Séverine
Bourrhis, Véronique
Vélayoudom-Céphise, Fritz-Line
author_sort Larifla, Laurent
collection PubMed
description OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. METHODS: We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects. TaqMan assays were performed to genotype rs7412 and rs429358, the two variants that determine the APOE alleles ε2, ε3 and ε4. The association between APOE genotype and the lipid profile was analysed by comparing ε2 carriers, ε3 homozygotes and ε4 carriers. RESULTS: The frequencies of ε2, ε3 and ε4 in the overall sample were 8%, 70% and 22%, respectively. CAD was not associated with APOE polymorphism. The total cholesterol level was higher in ε4 carriers compared with ε2 carriers: 5.07 vs 4.59 mmol/L (P = 0.016). The LDL-cholesterol level was lower in APOE ε2 carriers compared with ε3 homozygotes and ε4 carriers: 2.65 vs 3.03 and 3.17 mmol/L, respectively (p = 0.002). The total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios were similar in the three allelic groups. APOE polymorphism was not associated with diabetes, hypertension, waist circumference or body mass index. CONCLUSIONS: Our results indicate that APOE gene polymorphism is associated with the lipid profile but not with CAD in Afro-Caribbean people. This lack of association with CAD may be explained by the low atherogenic profile observed in ε4 carriers, which may warrant further investigation.
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spelling pubmed-55191722017-08-07 Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans Larifla, Laurent Armand, Christophe Bangou, Jacqueline Blanchet-Deverly, Anne Numeric, Patrick Fonteau, Christiane Michel, Carl-Thony Ferdinand, Séverine Bourrhis, Véronique Vélayoudom-Céphise, Fritz-Line PLoS One Research Article OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. METHODS: We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects. TaqMan assays were performed to genotype rs7412 and rs429358, the two variants that determine the APOE alleles ε2, ε3 and ε4. The association between APOE genotype and the lipid profile was analysed by comparing ε2 carriers, ε3 homozygotes and ε4 carriers. RESULTS: The frequencies of ε2, ε3 and ε4 in the overall sample were 8%, 70% and 22%, respectively. CAD was not associated with APOE polymorphism. The total cholesterol level was higher in ε4 carriers compared with ε2 carriers: 5.07 vs 4.59 mmol/L (P = 0.016). The LDL-cholesterol level was lower in APOE ε2 carriers compared with ε3 homozygotes and ε4 carriers: 2.65 vs 3.03 and 3.17 mmol/L, respectively (p = 0.002). The total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios were similar in the three allelic groups. APOE polymorphism was not associated with diabetes, hypertension, waist circumference or body mass index. CONCLUSIONS: Our results indicate that APOE gene polymorphism is associated with the lipid profile but not with CAD in Afro-Caribbean people. This lack of association with CAD may be explained by the low atherogenic profile observed in ε4 carriers, which may warrant further investigation. Public Library of Science 2017-07-20 /pmc/articles/PMC5519172/ /pubmed/28727855 http://dx.doi.org/10.1371/journal.pone.0181620 Text en © 2017 Larifla et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Larifla, Laurent
Armand, Christophe
Bangou, Jacqueline
Blanchet-Deverly, Anne
Numeric, Patrick
Fonteau, Christiane
Michel, Carl-Thony
Ferdinand, Séverine
Bourrhis, Véronique
Vélayoudom-Céphise, Fritz-Line
Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans
title Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans
title_full Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans
title_fullStr Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans
title_full_unstemmed Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans
title_short Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans
title_sort association of apoe gene polymorphism with lipid profile and coronary artery disease in afro-caribbeans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519172/
https://www.ncbi.nlm.nih.gov/pubmed/28727855
http://dx.doi.org/10.1371/journal.pone.0181620
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