Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation

HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhibits wild-type HIV-1 infection more potently than...

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Detalles Bibliográficos
Autores principales: Zhyvoloup, Alexander, Melamed, Anat, Anderson, Ian, Planas, Delphine, Lee, Chen-Hsuin, Kriston-Vizi, Janos, Ketteler, Robin, Merritt, Andy, Routy, Jean-Pierre, Ancuta, Petronela, Bangham, Charles R. M., Fassati, Ariberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519191/
https://www.ncbi.nlm.nih.gov/pubmed/28727807
http://dx.doi.org/10.1371/journal.ppat.1006460

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