Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system

Toxoplasma gondii is one of the world’s most successful parasites, in part because of its ability to infect and persist in most warm-blooded animals. A unique characteristic of T. gondii is its ability to persist in the central nervous system (CNS) of a variety of hosts, including humans and rodents...

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Autores principales: Mendez, Oscar A., Koshy, Anita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519211/
https://www.ncbi.nlm.nih.gov/pubmed/28727854
http://dx.doi.org/10.1371/journal.ppat.1006351
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author Mendez, Oscar A.
Koshy, Anita A.
author_facet Mendez, Oscar A.
Koshy, Anita A.
author_sort Mendez, Oscar A.
collection PubMed
description Toxoplasma gondii is one of the world’s most successful parasites, in part because of its ability to infect and persist in most warm-blooded animals. A unique characteristic of T. gondii is its ability to persist in the central nervous system (CNS) of a variety of hosts, including humans and rodents. How, what, and why T. gondii encysts in the CNS has been the topic of study for decades. In this review, we will discuss recent work on how T. gondii is able to traverse the unique barrier surrounding the CNS, what cells of the CNS play host to T. gondii, and finally, how T. gondii infection may influence global and cellular physiology of the CNS.
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spelling pubmed-55192112017-08-07 Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system Mendez, Oscar A. Koshy, Anita A. PLoS Pathog Review Toxoplasma gondii is one of the world’s most successful parasites, in part because of its ability to infect and persist in most warm-blooded animals. A unique characteristic of T. gondii is its ability to persist in the central nervous system (CNS) of a variety of hosts, including humans and rodents. How, what, and why T. gondii encysts in the CNS has been the topic of study for decades. In this review, we will discuss recent work on how T. gondii is able to traverse the unique barrier surrounding the CNS, what cells of the CNS play host to T. gondii, and finally, how T. gondii infection may influence global and cellular physiology of the CNS. Public Library of Science 2017-07-20 /pmc/articles/PMC5519211/ /pubmed/28727854 http://dx.doi.org/10.1371/journal.ppat.1006351 Text en © 2017 Mendez, Koshy http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Mendez, Oscar A.
Koshy, Anita A.
Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system
title Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system
title_full Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system
title_fullStr Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system
title_full_unstemmed Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system
title_short Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system
title_sort toxoplasma gondii: entry, association, and physiological influence on the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519211/
https://www.ncbi.nlm.nih.gov/pubmed/28727854
http://dx.doi.org/10.1371/journal.ppat.1006351
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