Compromised BRCA1-PALB2 interaction is associated with breast cancer risk

The major breast cancer suppressor proteins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which is thought to be critical for tumor suppression. The two BRCA proteins are linked by a third tumor suppressor, PALB2, in the HR pathway. While truncating mutat...

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Detalles Bibliográficos
Autores principales: Foo, Tzeh Keong, Tischkowitz, Marc, Simhadri, Srilatha, Boshari, Talia, Zayed, Nadia, Burke, Kathleen A., Berman, Samuel H., Blecua, Pedro, Riaz, Nadeem, Huo, Yanying, Ding, Yuan Chun, Neuhausen, Susan L., Weigelt, Britta, Reis-Filho, Jorge S., Foulkes, William D., Xia, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519427/
https://www.ncbi.nlm.nih.gov/pubmed/28319063
http://dx.doi.org/10.1038/onc.2017.46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519427/
https://www.ncbi.nlm.nih.gov/pubmed/28319063
http://dx.doi.org/10.1038/onc.2017.46

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