A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis

A 71-year-old man with hypertension and diabetes mellitus presented with proteinuria. Laboratory data showed proteinuria of 3.1 g/g creatinine, serum albumin of 3.5 g/dL and serum creatinine of 1.03 mg/dL without autoantibodies. A renal biopsy revealed segmental granular IgG depositions on glomerula...

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Autores principales: Fujigaki, Yoshihide, Tamura, Yoshifuru, Shibata, Shigeru, Kondo, Fukuo, Iwakura, Takamasa, Kojima, Kenichiro, Yamaguchi, Yutaka, Uchida, Shunya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519472/
https://www.ncbi.nlm.nih.gov/pubmed/28674359
http://dx.doi.org/10.2169/internalmedicine.56.8298
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author Fujigaki, Yoshihide
Tamura, Yoshifuru
Shibata, Shigeru
Kondo, Fukuo
Iwakura, Takamasa
Kojima, Kenichiro
Yamaguchi, Yutaka
Uchida, Shunya
author_facet Fujigaki, Yoshihide
Tamura, Yoshifuru
Shibata, Shigeru
Kondo, Fukuo
Iwakura, Takamasa
Kojima, Kenichiro
Yamaguchi, Yutaka
Uchida, Shunya
author_sort Fujigaki, Yoshihide
collection PubMed
description A 71-year-old man with hypertension and diabetes mellitus presented with proteinuria. Laboratory data showed proteinuria of 3.1 g/g creatinine, serum albumin of 3.5 g/dL and serum creatinine of 1.03 mg/dL without autoantibodies. A renal biopsy revealed segmental granular IgG depositions on glomerular capillary walls. Electron microscopy showed segmentally subepithelial, intramembranous and mesangial deposits. Diffuse segmental membranous glomerulonephritis (MGN) was diagnosed with only IgG1 deposition and without M-type phospholipase A2 receptor or thrombospondin type-1 domain-containing 7A staining, suggesting secondary MGN with an unknown target antigen in immune deposits. Physicians should keep in mind the existence of segmental MGN to better understand the clinicopathological characteristics.
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spelling pubmed-55194722017-07-27 A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis Fujigaki, Yoshihide Tamura, Yoshifuru Shibata, Shigeru Kondo, Fukuo Iwakura, Takamasa Kojima, Kenichiro Yamaguchi, Yutaka Uchida, Shunya Intern Med Case Report A 71-year-old man with hypertension and diabetes mellitus presented with proteinuria. Laboratory data showed proteinuria of 3.1 g/g creatinine, serum albumin of 3.5 g/dL and serum creatinine of 1.03 mg/dL without autoantibodies. A renal biopsy revealed segmental granular IgG depositions on glomerular capillary walls. Electron microscopy showed segmentally subepithelial, intramembranous and mesangial deposits. Diffuse segmental membranous glomerulonephritis (MGN) was diagnosed with only IgG1 deposition and without M-type phospholipase A2 receptor or thrombospondin type-1 domain-containing 7A staining, suggesting secondary MGN with an unknown target antigen in immune deposits. Physicians should keep in mind the existence of segmental MGN to better understand the clinicopathological characteristics. The Japanese Society of Internal Medicine 2017-07-01 /pmc/articles/PMC5519472/ /pubmed/28674359 http://dx.doi.org/10.2169/internalmedicine.56.8298 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Fujigaki, Yoshihide
Tamura, Yoshifuru
Shibata, Shigeru
Kondo, Fukuo
Iwakura, Takamasa
Kojima, Kenichiro
Yamaguchi, Yutaka
Uchida, Shunya
A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
title A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
title_full A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
title_fullStr A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
title_full_unstemmed A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
title_short A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
title_sort rare adult case with diffuse segmental membranous glomerulonephritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519472/
https://www.ncbi.nlm.nih.gov/pubmed/28674359
http://dx.doi.org/10.2169/internalmedicine.56.8298
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