Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review

We herein report a 73-year-old Japanese woman with metastatic thymic carcinoma who developed diffuse alveolar hemorrhage (DAH) during irinotecan chemotherapy. She presented with a mild fever and exertional dyspnea after the second cycle of weekly irinotecan monotherapy. Chest images showed diffuse g...

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Autores principales: Kim, Sung-Ho, Minami, Seigo, Ogata, Yoshitaka, Yamamoto, Suguru, Komuta, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519473/
https://www.ncbi.nlm.nih.gov/pubmed/28674360
http://dx.doi.org/10.2169/internalmedicine.56.8349
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author Kim, Sung-Ho
Minami, Seigo
Ogata, Yoshitaka
Yamamoto, Suguru
Komuta, Kiyoshi
author_facet Kim, Sung-Ho
Minami, Seigo
Ogata, Yoshitaka
Yamamoto, Suguru
Komuta, Kiyoshi
author_sort Kim, Sung-Ho
collection PubMed
description We herein report a 73-year-old Japanese woman with metastatic thymic carcinoma who developed diffuse alveolar hemorrhage (DAH) during irinotecan chemotherapy. She presented with a mild fever and exertional dyspnea after the second cycle of weekly irinotecan monotherapy. Chest images showed diffuse ground-glass opacities. The diagnosis of DAH was based on the findings of the bronchoalveolar lavage fluid, which was bloody and contained hemosiderin-laden macrophages. The discontinuation of irinotecan and introduction of oral prednisolone improved her symptoms and chest abnormal shadows. This is the first case of DAH caused by irinotecan.
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spelling pubmed-55194732017-07-27 Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review Kim, Sung-Ho Minami, Seigo Ogata, Yoshitaka Yamamoto, Suguru Komuta, Kiyoshi Intern Med Case Report We herein report a 73-year-old Japanese woman with metastatic thymic carcinoma who developed diffuse alveolar hemorrhage (DAH) during irinotecan chemotherapy. She presented with a mild fever and exertional dyspnea after the second cycle of weekly irinotecan monotherapy. Chest images showed diffuse ground-glass opacities. The diagnosis of DAH was based on the findings of the bronchoalveolar lavage fluid, which was bloody and contained hemosiderin-laden macrophages. The discontinuation of irinotecan and introduction of oral prednisolone improved her symptoms and chest abnormal shadows. This is the first case of DAH caused by irinotecan. The Japanese Society of Internal Medicine 2017-07-01 /pmc/articles/PMC5519473/ /pubmed/28674360 http://dx.doi.org/10.2169/internalmedicine.56.8349 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kim, Sung-Ho
Minami, Seigo
Ogata, Yoshitaka
Yamamoto, Suguru
Komuta, Kiyoshi
Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review
title Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review
title_full Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review
title_fullStr Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review
title_full_unstemmed Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review
title_short Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review
title_sort diffuse alveolar hemorrhage induced by irinotecan for a patient with metastatic thymic carcinoma: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519473/
https://www.ncbi.nlm.nih.gov/pubmed/28674360
http://dx.doi.org/10.2169/internalmedicine.56.8349
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