EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine

We report a case of secondary diffuse large B-cell lymphoma (DLBCL) after azacitidine (AZA) treatment in a 63-years-old man with myelodysplastic syndrome. The patient suffered from febrile neutropenia after 10 cycles of AZA treatment. Despite the performance of a whole-body CT scan, which showed a m...

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Autores principales: Suzuki, Naruko, Hiraga, Junji, Kato, Hiroki, Takagi, Yusuke, Ujihira, Nobuko, Narita, Michihiko, Kagami, Yoshitoyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519476/
https://www.ncbi.nlm.nih.gov/pubmed/28674363
http://dx.doi.org/10.2169/internalmedicine.56.7865
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author Suzuki, Naruko
Hiraga, Junji
Kato, Hiroki
Takagi, Yusuke
Ujihira, Nobuko
Narita, Michihiko
Kagami, Yoshitoyo
author_facet Suzuki, Naruko
Hiraga, Junji
Kato, Hiroki
Takagi, Yusuke
Ujihira, Nobuko
Narita, Michihiko
Kagami, Yoshitoyo
author_sort Suzuki, Naruko
collection PubMed
description We report a case of secondary diffuse large B-cell lymphoma (DLBCL) after azacitidine (AZA) treatment in a 63-years-old man with myelodysplastic syndrome. The patient suffered from febrile neutropenia after 10 cycles of AZA treatment. Despite the performance of a whole-body CT scan, which showed a multifocal low-density area in the liver and a multifocal nodular shadow in the lung, no malignant neoplasms could be detected. An autopsy was performed 6 months later, and a histopathological examination of the lesions of the liver and lung revealed the infiltration of large round-shaped tumor cells with necrotizing lesions. Immunohistochemically, the tumor cells were positive for CD20 and EBER, indicating EBV-positive DLBCL as a secondary malignancy.
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spelling pubmed-55194762017-07-27 EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine Suzuki, Naruko Hiraga, Junji Kato, Hiroki Takagi, Yusuke Ujihira, Nobuko Narita, Michihiko Kagami, Yoshitoyo Intern Med Case Report We report a case of secondary diffuse large B-cell lymphoma (DLBCL) after azacitidine (AZA) treatment in a 63-years-old man with myelodysplastic syndrome. The patient suffered from febrile neutropenia after 10 cycles of AZA treatment. Despite the performance of a whole-body CT scan, which showed a multifocal low-density area in the liver and a multifocal nodular shadow in the lung, no malignant neoplasms could be detected. An autopsy was performed 6 months later, and a histopathological examination of the lesions of the liver and lung revealed the infiltration of large round-shaped tumor cells with necrotizing lesions. Immunohistochemically, the tumor cells were positive for CD20 and EBER, indicating EBV-positive DLBCL as a secondary malignancy. The Japanese Society of Internal Medicine 2017-07-01 /pmc/articles/PMC5519476/ /pubmed/28674363 http://dx.doi.org/10.2169/internalmedicine.56.7865 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Suzuki, Naruko
Hiraga, Junji
Kato, Hiroki
Takagi, Yusuke
Ujihira, Nobuko
Narita, Michihiko
Kagami, Yoshitoyo
EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine
title EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine
title_full EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine
title_fullStr EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine
title_full_unstemmed EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine
title_short EBV-positive Diffuse Large B-cell Lymphoma as a Secondary Malignancy Arising in a Myelodysplastic Syndrome Patient who Was Treated with Azacitidine
title_sort ebv-positive diffuse large b-cell lymphoma as a secondary malignancy arising in a myelodysplastic syndrome patient who was treated with azacitidine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519476/
https://www.ncbi.nlm.nih.gov/pubmed/28674363
http://dx.doi.org/10.2169/internalmedicine.56.7865
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