Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals

Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM(+) plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM(+) B cells disseminated throughout the intestine b...

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Detalles Bibliográficos
Autores principales: Magri, Giuliana, Comerma, Laura, Pybus, Marc, Sintes, Jordi, Lligé, David, Segura-Garzón, Daniel, Bascones, Sabrina, Yeste, Ada, Grasset, Emilie K., Gutzeit, Cindy, Uzzan, Mathieu, Ramanujam, Meera, van Zelm, Menno C., Albero-González, Raquel, Vazquez, Ivonne, Iglesias, Mar, Serrano, Sergi, Márquez, Lucía, Mercade, Elena, Mehandru, Saurabh, Cerutti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519504/
https://www.ncbi.nlm.nih.gov/pubmed/28709802
http://dx.doi.org/10.1016/j.immuni.2017.06.013

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