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Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells

Ionizing radiation (IR) induces DNA double-strand breaks (DSBs), which are an initial step towards chromosomal aberrations and cell death. It has been suggested that there are individual differences in radiosensitivity within human populations, and that the variations in DNA repair genes might deter...

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Detalles Bibliográficos
Autores principales:	Royba, Ekaterina, Miyamoto, Tatsuo, Natsuko Akutsu, Silvia, Hosoba, Kosuke, Tauchi, Hiroshi, Kudo, Yoshiki, Tashiro, Satoshi, Yamamoto, Takashi, Matsuura, Shinya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519549/ https://www.ncbi.nlm.nih.gov/pubmed/28729543 http://dx.doi.org/10.1038/s41598-017-06393-8

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