Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented...

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Detalles Bibliográficos
Autores principales: De Koker, S., Van Hoecke, L., De Beuckelaer, A., Roose, K., Deswarte, K., Willart, M. A., Bogaert, P., Naessens, T., De Geest, B. G., Saelens, X., Lambrecht, B. N., Grooten, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519561/
https://www.ncbi.nlm.nih.gov/pubmed/28729715
http://dx.doi.org/10.1038/s41598-017-06236-6

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