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Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What?

The auditory brainstem response (ABR) in tinnitus subjects has been extensively investigated over the last decade with the hopes of finding possible abnormalities related to the pathology. Despite this effort, the use of the ABR for tinnitus diagnosis or as an outcome measure is under debate. The pr...

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Autores principales: Milloy, Victoria, Fournier, Philippe, Benoit, Daniel, Noreña, Arnaud, Koravand, Amineh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519563/
https://www.ncbi.nlm.nih.gov/pubmed/28785218
http://dx.doi.org/10.3389/fnagi.2017.00237
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author Milloy, Victoria
Fournier, Philippe
Benoit, Daniel
Noreña, Arnaud
Koravand, Amineh
author_facet Milloy, Victoria
Fournier, Philippe
Benoit, Daniel
Noreña, Arnaud
Koravand, Amineh
author_sort Milloy, Victoria
collection PubMed
description The auditory brainstem response (ABR) in tinnitus subjects has been extensively investigated over the last decade with the hopes of finding possible abnormalities related to the pathology. Despite this effort, the use of the ABR for tinnitus diagnosis or as an outcome measure is under debate. The present study reviewed published literature on ABR and tinnitus. The authors searched PubMed, MedLine, Embase, PsycINFO, and CINAHL, and identified additional records through manually searching reference lists and gray literature. There were 4,566 articles identified through database searching and 151 additional studies through the manual search (4,717 total): 2,128 articles were removed as duplicates, and 2,567 records did not meet eligibility criteria. From the final 22 articles that were included, ABR results from 1,240 tinnitus subjects and 664 control subjects were compiled and summarized with a focus on three main areas: the participant characteristics, the methodology used, and the outcome measures of amplitude and/or latency of waves I, III, and V. The results indicate a high level of heterogeneity between the studies for all the assessed areas. Amplitude and latency differences between tinnitus and controls were not consistent between studies. Nevertheless, the longer latency and reduced amplitude of wave I for the tinnitus group with normal hearing compared to matched controls was the most consistent finding across studies. These results support the need for greater stratification of the tinnitus population and the importance of a standardized ABR method to make comparisons between studies possible.
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spelling pubmed-55195632017-08-07 Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What? Milloy, Victoria Fournier, Philippe Benoit, Daniel Noreña, Arnaud Koravand, Amineh Front Aging Neurosci Neuroscience The auditory brainstem response (ABR) in tinnitus subjects has been extensively investigated over the last decade with the hopes of finding possible abnormalities related to the pathology. Despite this effort, the use of the ABR for tinnitus diagnosis or as an outcome measure is under debate. The present study reviewed published literature on ABR and tinnitus. The authors searched PubMed, MedLine, Embase, PsycINFO, and CINAHL, and identified additional records through manually searching reference lists and gray literature. There were 4,566 articles identified through database searching and 151 additional studies through the manual search (4,717 total): 2,128 articles were removed as duplicates, and 2,567 records did not meet eligibility criteria. From the final 22 articles that were included, ABR results from 1,240 tinnitus subjects and 664 control subjects were compiled and summarized with a focus on three main areas: the participant characteristics, the methodology used, and the outcome measures of amplitude and/or latency of waves I, III, and V. The results indicate a high level of heterogeneity between the studies for all the assessed areas. Amplitude and latency differences between tinnitus and controls were not consistent between studies. Nevertheless, the longer latency and reduced amplitude of wave I for the tinnitus group with normal hearing compared to matched controls was the most consistent finding across studies. These results support the need for greater stratification of the tinnitus population and the importance of a standardized ABR method to make comparisons between studies possible. Frontiers Media S.A. 2017-07-21 /pmc/articles/PMC5519563/ /pubmed/28785218 http://dx.doi.org/10.3389/fnagi.2017.00237 Text en Copyright © 2017 Milloy, Fournier, Benoit, Noreña and Koravand. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Milloy, Victoria
Fournier, Philippe
Benoit, Daniel
Noreña, Arnaud
Koravand, Amineh
Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What?
title Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What?
title_full Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What?
title_fullStr Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What?
title_full_unstemmed Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What?
title_short Auditory Brainstem Responses in Tinnitus: A Review of Who, How, and What?
title_sort auditory brainstem responses in tinnitus: a review of who, how, and what?
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519563/
https://www.ncbi.nlm.nih.gov/pubmed/28785218
http://dx.doi.org/10.3389/fnagi.2017.00237
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