Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

BACKGROUND: Streptococcus pneumoniae is a major etiologic agent of bacterial pneumonia. Autolysis and antibiotic-mediated lysis of pneumococci induce release of the pore-forming toxin, pneumolysin (PLY), their major virulence factor, which is a prominent cause of acute lung injury. PLY inhibits alve...

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Detalles Bibliográficos
Autores principales: Czikora, Istvan, Alli, Abdel A., Sridhar, Supriya, Matthay, Michael A., Pillich, Helena, Hudel, Martina, Berisha, Besim, Gorshkov, Boris, Romero, Maritza J., Gonzales, Joyce, Wu, Guangyu, Huo, Yuqing, Su, Yunchao, Verin, Alexander D., Fulton, David, Chakraborty, Trinad, Eaton, Douglas C., Lucas, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519615/
https://www.ncbi.nlm.nih.gov/pubmed/28785264
http://dx.doi.org/10.3389/fimmu.2017.00842

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