Cargando…

Effects of 4(1H)-quinolinone derivative, a novel non-nucleotide allosteric purinergic P2Y(2) agonist, on cardiomyocytes in neonatal rats

Purinergic P2Y(2) receptors, G-protein coupled receptors that primarily couple with Gα(q/11)-proteins, are activated equipotently by adenosine-5′-triphosphate (ATP) and uridine-5′-triphosphate. Evidence suggests that P2Y(2) agonists make potential drug candidates for the treatment of cardiovascular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakuma, Kensuke, Nakagawa, Hideyuki, Oikawa, Tatsuo, Noda, Masakuni, Ikeda, Shota
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519634/ https://www.ncbi.nlm.nih.gov/pubmed/28729619 http://dx.doi.org/10.1038/s41598-017-06481-9

Ejemplares similares

Recent Syntheses of 1,2,3,4-Tetrahydroquinolines, 2,3-Dihydro-4(1H)-quinolinones and 4(1H)-Quinolinones using Domino Reactions
por: Nammalwar, Baskar, et al.
Publicado: (2013)

Microwave assisted one-pot access to pyrazolo quinolinone and tetrahydroisoxazolo quinolinone derivatives via T3P®-DMSO catalysed tandem oxidative–condensation reaction
por: Gowda, Darshini, et al.
Publicado: (2023)

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy
por: Bautista-Aguilera, Óscar M., et al.
Publicado: (2020)

Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts
por: Nanke, Yuki, et al.
Publicado: (2016)

Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents
por: Castro, Helena, et al.
Publicado: (2020)

Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules
por: Stoiber, Patrick, et al.
Publicado: (2021)

New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
por: Weiss, Matjaž, et al.
Publicado: (2021)

Design, Synthesis, and Pharmacology of New Triazole-Containing Quinolinones as CNS Active Agents
por: Zhao, Wennan, et al.
Publicado: (2023)

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
por: Harnden, Alice C., et al.
Publicado: (2023)

Cardiomyocyte death induced by ischaemic/hypoxic stress is differentially affected by distinct purinergic P2 receptors
por: Cosentino, Simona, et al.
Publicado: (2012)

Cytotoxicity of Amino‐BODIPY Modulated via Conjugation with 2‐Phenyl‐3‐Hydroxy‐4(1H)‐Quinolinones
por: Porubský, Martin, et al.
Publicado: (2021)

Erratum to: Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Purinergic Signalling
por: Kukulski, F., et al.
Publicado: (2005)

Pyridine-2-carboxylic acid as an effectual catalyst for rapid multi-component synthesis of pyrazolo[3,4-b]quinolinones
por: Sharma, Mayank G., et al.
Publicado: (2020)

Neonatal Seizures and Purinergic Signalling
por: Menéndez Méndez, Aida, et al.
Publicado: (2020)

Novel Schiff Bases Based on the Quinolinone Skeleton: Syntheses, X-ray Structures and Fluorescent Properties
por: Trávníček, Zdeněk, et al.
Publicado: (2014)

One-pot synthesis of indoles and quinolinones from ortho-tosylaminophenyl-substituted para-quinone methides
por: Wang, Junwei, et al.
Publicado: (2020)

Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins
por: Yunes, Sarah A., et al.
Publicado: (2022)

Olaparib Conjugates with Selenopheno[3,2-c]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance
por: Makrecka-Kuka, Marina, et al.
Publicado: (2022)

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides
por: DeBerg, Hannah A., et al.
Publicado: (2016)

G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
por: Hino, Tomoya, et al.
Publicado: (2012)

Synthesis, Structural Determination, and Antioxidant Activities of Acyclic and Substituted Heterocyclic Phosphonates Linearly Linked 4-hydroxy-2(1H)-quinolinone
por: Hassan, Mohamed M., et al.
Publicado: (2022)

A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants
por: Makau, Juliann Nzembi, et al.
Publicado: (2020)

Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids
por: El-Sheref, Essmat M., et al.
Publicado: (2020)

The Role of Nucleotides and Purinergic Signaling in Apoptotic Cell Clearance – Implications for Chronic Inflammatory Diseases
por: Chen, Jin, et al.
Publicado: (2014)

Purinergic smooth muscle contractions in the human prostate: estimation of relevance and characterization of different agonists
por: Spek, Annabel, et al.
Publicado: (2021)

Allosteric modulator potentiates β(2)AR agonist–promoted bronchoprotection in asthma models
por: Ahn, Seungkirl, et al.
Publicado: (2023)

The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases
por: Buey, Rubén M., et al.
Publicado: (2022)

Discovery of Novel 3,4-Dihydro-2(1H)-Quinolinone Sulfonamide Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity
por: Ma, Juan, et al.
Publicado: (2022)

The Purinergic Landscape of Type 2 Diabetes Mellitus
por: Garcia-Jacobo, Rocio Edith, et al.
Publicado: (2022)

Two Single Nucleotide Polymorphisms in the Purinergic Receptor P2X7 Gene Are Associated with Disease Severity in Multiple Sclerosis
por: Guerini, Franca Rosa, et al.
Publicado: (2022)

Guanosine-Based Nucleotides, the Sons of a Lesser God in the Purinergic Signal Scenario of Excitable Tissues
por: Mancinelli, Rosa, et al.
Publicado: (2020)

The Conserved Lysine-265 Allosterically Modulates Nucleotide- and Actin-binding Site Coupling in Myosin-2
por: Behrens, Vincent A., et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease
por: Guo, Jie, et al.
Publicado: (2022)

Purinergic cotransmission
por: Burnstock, Geoffrey
Publicado: (2009)

Assessing potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor by the allosteric agonist CMPI
por: Deba, Farah, et al.
Publicado: (2021)

Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease
por: Fu, Jie, et al.
Publicado: (2019)

Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp
por: Laiolo, Jerónimo, et al.
Publicado: (2021)

Mechanism of Allosteric Modulation of Rod Cyclic Nucleotide–gated Channels
por: Sunderman, Elizabeth R., et al.
Publicado: (1999)

Purinergic P2 Receptors: Structure and Function 2.0
por: Zemkova, Hana
Publicado: (2023)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_og69blfbt5s2lbirkmjf2q3uov