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Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc(Min/+) mouse model of intestinal tumorigenesis

Genetic deletion or pharmacological inhibition of cyclooxygenase (COX)-2 abrogates intestinal adenoma development at early stages of colorectal carcinogenesis. COX-2 is localised to stromal cells (predominantly macrophages) in human and mouse intestinal adenomas. Therefore, we tested the hypothesis...

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Detalles Bibliográficos
Autores principales:	Hull, Mark A., Cuthbert, Richard J., Ko, C. W. Stanley, Scott, Daniel J., Cartwright, Elizabeth J., Hawcroft, Gillian, Perry, Sarah L., Ingram, Nicola, Carr, Ian M., Markham, Alexander F., Bonifer, Constanze, Coletta, P. Louise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519705/ https://www.ncbi.nlm.nih.gov/pubmed/28729694 http://dx.doi.org/10.1038/s41598-017-06253-5

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