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DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling complex, are critical in chromatin structure regulation. Here, we show that the human BRM (hBRM) bromodomain (BRD) has moderate specificity for H3K14ac. Surprisingly, we also find that both BRG1 and hBRM BRDs have DNA-bindi...

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Detalles Bibliográficos
Autores principales:	Morrison, Emma A., Sanchez, Julio C., Ronan, Jehnna L., Farrell, Daniel P., Varzavand, Katayoun, Johnson, Jenna K., Gu, Brian X., Crabtree, Gerald R., Musselman, Catherine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519978/ https://www.ncbi.nlm.nih.gov/pubmed/28706277 http://dx.doi.org/10.1038/ncomms16080

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