Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

Ras mutations are the oncogenic drivers of many human cancers and yet there are still no approved Ras-targeted cancer therapies. Inhibition of Ras nucleotide exchange is a promising new approach but better understanding of this mechanism of action is needed. Here we describe an antibody mimetic, DAR...

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Detalles Bibliográficos
Autores principales: Guillard, Sandrine, Kolasinska-Zwierz, Paulina, Debreczeni, Judit, Breed, Jason, Zhang, Jing, Bery, Nicolas, Marwood, Rose, Tart, Jon, Overman, Ross, Stocki, Pawel, Mistry, Bina, Phillips, Christopher, Rabbitts, Terence, Jackson, Ronald, Minter, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519984/
https://www.ncbi.nlm.nih.gov/pubmed/28706291
http://dx.doi.org/10.1038/ncomms16111

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