Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Retinoid X receptor-alpha (RXRα) binds to DNA either as homodimers or heterodimers, but it also forms homotetramers whose function is poorly defined. We previously discovered that an N-terminally-cleaved form of RXRα (tRXRα), produced in tumour cells, activates phosphoinositide 3-kinase (PI3K) signa...

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Detalles Bibliográficos
Autores principales: Chen, Liqun, Aleshin, Alexander E., Alitongbieke, Gulimiran, Zhou, Yuqi, Zhang, Xindao, Ye, Xiaohong, Hu, Mengjie, Ren, Gaoang, Chen, Ziwen, Ma, Yue, Zhang, Duo, Liu, Shuai, Gao, Weiwei, Cai, Lijun, Wu, Lingjuan, Zeng, Zhiping, Jiang, Fuquan, Liu, Jie, Zhou, Hu, Cadwell, Gregory, Liddington, Robert C., Su, Ying, Zhang, Xiao-kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520057/
https://www.ncbi.nlm.nih.gov/pubmed/28714476
http://dx.doi.org/10.1038/ncomms16066

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