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Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial

BACKGROUND: The advantages of adapted physical activity and nutritional education (APANE) on breast cancer prognosis and quality of life (QoL) are well known, but long-term results are lacking. METHODS: A randomised controlled trial testing a 2-week intervention in hydrothermal centres including APA...

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Autores principales: Kwiatkowski, Fabrice, Mouret-Reynier, Marie-Ange, Duclos, Martine, Bridon, François, Hanh, Thierry, Van Praagh-Doreau, Isabelle, Travade, Armelle, Vasson, Marie-Paule, Jouvency, Sylvie, Roques, Christian, Bignon, Yves-Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520091/
https://www.ncbi.nlm.nih.gov/pubmed/28427084
http://dx.doi.org/10.1038/bjc.2017.112
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author Kwiatkowski, Fabrice
Mouret-Reynier, Marie-Ange
Duclos, Martine
Bridon, François
Hanh, Thierry
Van Praagh-Doreau, Isabelle
Travade, Armelle
Vasson, Marie-Paule
Jouvency, Sylvie
Roques, Christian
Bignon, Yves-Jean
author_facet Kwiatkowski, Fabrice
Mouret-Reynier, Marie-Ange
Duclos, Martine
Bridon, François
Hanh, Thierry
Van Praagh-Doreau, Isabelle
Travade, Armelle
Vasson, Marie-Paule
Jouvency, Sylvie
Roques, Christian
Bignon, Yves-Jean
author_sort Kwiatkowski, Fabrice
collection PubMed
description BACKGROUND: The advantages of adapted physical activity and nutritional education (APANE) on breast cancer prognosis and quality of life (QoL) are well known, but long-term results are lacking. METHODS: A randomised controlled trial testing a 2-week intervention in hydrothermal centres including APANE enrolled 251 patients post-chemotherapy. QoL and weight control were significantly improved at 12 months. A 5-year follow-up was performed to evaluate the persistence of improvements. RESULTS: QoL increase (SF36) was persistent: effect-size at 2, 3, 4 and 5 years equalled respectively 0.27 (−0.01; 0.56), 0.28 (−0.02; 0.58), 0.41 (0.02; 0.81) and 0.45 (0.11; 0.80). Weight control observed after intervention lasted 2 years: 2.7% decrease at 1 year (P=0.0085), 2.5% at 2 years (P=0.025); and respectively for waist −2.4% (−3.6; −1.1) (P=0.000014) and −1.3% (−2.5; −0.1) (P=0.0072). CONCLUSIONS: A 2-week intervention in hydrothermal centres performed shortly after chemotherapy can durably improve breast cancer patients’ QoL and reduce weight.
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spelling pubmed-55200912018-05-23 Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial Kwiatkowski, Fabrice Mouret-Reynier, Marie-Ange Duclos, Martine Bridon, François Hanh, Thierry Van Praagh-Doreau, Isabelle Travade, Armelle Vasson, Marie-Paule Jouvency, Sylvie Roques, Christian Bignon, Yves-Jean Br J Cancer Clinical Study BACKGROUND: The advantages of adapted physical activity and nutritional education (APANE) on breast cancer prognosis and quality of life (QoL) are well known, but long-term results are lacking. METHODS: A randomised controlled trial testing a 2-week intervention in hydrothermal centres including APANE enrolled 251 patients post-chemotherapy. QoL and weight control were significantly improved at 12 months. A 5-year follow-up was performed to evaluate the persistence of improvements. RESULTS: QoL increase (SF36) was persistent: effect-size at 2, 3, 4 and 5 years equalled respectively 0.27 (−0.01; 0.56), 0.28 (−0.02; 0.58), 0.41 (0.02; 0.81) and 0.45 (0.11; 0.80). Weight control observed after intervention lasted 2 years: 2.7% decrease at 1 year (P=0.0085), 2.5% at 2 years (P=0.025); and respectively for waist −2.4% (−3.6; −1.1) (P=0.000014) and −1.3% (−2.5; −0.1) (P=0.0072). CONCLUSIONS: A 2-week intervention in hydrothermal centres performed shortly after chemotherapy can durably improve breast cancer patients’ QoL and reduce weight. Nature Publishing Group 2017-05-23 2017-04-20 /pmc/articles/PMC5520091/ /pubmed/28427084 http://dx.doi.org/10.1038/bjc.2017.112 Text en Copyright © 2017 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Clinical Study
Kwiatkowski, Fabrice
Mouret-Reynier, Marie-Ange
Duclos, Martine
Bridon, François
Hanh, Thierry
Van Praagh-Doreau, Isabelle
Travade, Armelle
Vasson, Marie-Paule
Jouvency, Sylvie
Roques, Christian
Bignon, Yves-Jean
Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial
title Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial
title_full Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial
title_fullStr Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial
title_full_unstemmed Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial
title_short Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial
title_sort long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘pacthe’ trial
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520091/
https://www.ncbi.nlm.nih.gov/pubmed/28427084
http://dx.doi.org/10.1038/bjc.2017.112
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