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Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction

[Image: see text] Metabolic incorporation of azide- or alkyne-modified sialic acids into the cellular glycosylation pathway enables the study of sialoglycan expression, localization, and trafficking via bioorthogonal chemistry. Herein, we report that such modifications of the sialic acid sugar can h...

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Detalles Bibliográficos
Autores principales:	Heise, Torben, Büll, Christian, Beurskens, Daniëlle M., Rossing, Emiel, de Jonge, Marien I., Adema, Gosse J., Boltje, Thomas J., Langereis, Jeroen D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520103/ https://www.ncbi.nlm.nih.gov/pubmed/28635265 http://dx.doi.org/10.1021/acs.bioconjchem.7b00224

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