Cargando…
Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on th...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520318/ https://www.ncbi.nlm.nih.gov/pubmed/28634355 http://dx.doi.org/10.1038/emi.2017.44 |
_version_ | 1783251794052251648 |
---|---|
author | Hemida, Maged Gomaa Alnaeem, Abdulmohsen Chu, Daniel KW Perera, Ranawaka APM Chan, Samuel MS Almathen, Faisal Yau, Emily Ng, Brian CY Webby, Richard J Poon, Leo LM Peiris, Malik |
author_facet | Hemida, Maged Gomaa Alnaeem, Abdulmohsen Chu, Daniel KW Perera, Ranawaka APM Chan, Samuel MS Almathen, Faisal Yau, Emily Ng, Brian CY Webby, Richard J Poon, Leo LM Peiris, Malik |
author_sort | Hemida, Maged Gomaa |
collection | PubMed |
description | Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission. |
format | Online Article Text |
id | pubmed-5520318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55203182017-08-21 Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 Hemida, Maged Gomaa Alnaeem, Abdulmohsen Chu, Daniel KW Perera, Ranawaka APM Chan, Samuel MS Almathen, Faisal Yau, Emily Ng, Brian CY Webby, Richard J Poon, Leo LM Peiris, Malik Emerg Microbes Infect Original Article Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission. Nature Publishing Group 2017-06 2017-06-21 /pmc/articles/PMC5520318/ /pubmed/28634355 http://dx.doi.org/10.1038/emi.2017.44 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Hemida, Maged Gomaa Alnaeem, Abdulmohsen Chu, Daniel KW Perera, Ranawaka APM Chan, Samuel MS Almathen, Faisal Yau, Emily Ng, Brian CY Webby, Richard J Poon, Leo LM Peiris, Malik Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 |
title | Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 |
title_full | Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 |
title_fullStr | Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 |
title_full_unstemmed | Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 |
title_short | Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 |
title_sort | longitudinal study of middle east respiratory syndrome coronavirus infection in dromedary camel herds in saudi arabia, 2014–2015 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520318/ https://www.ncbi.nlm.nih.gov/pubmed/28634355 http://dx.doi.org/10.1038/emi.2017.44 |
work_keys_str_mv | AT hemidamagedgomaa longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT alnaeemabdulmohsen longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT chudanielkw longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT pereraranawakaapm longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT chansamuelms longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT almathenfaisal longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT yauemily longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT ngbriancy longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT webbyrichardj longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT poonleolm longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 AT peirismalik longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015 |