Cargando…

Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015

Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on th...

Descripción completa

Detalles Bibliográficos
Autores principales: Hemida, Maged Gomaa, Alnaeem, Abdulmohsen, Chu, Daniel KW, Perera, Ranawaka APM, Chan, Samuel MS, Almathen, Faisal, Yau, Emily, Ng, Brian CY, Webby, Richard J, Poon, Leo LM, Peiris, Malik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520318/
https://www.ncbi.nlm.nih.gov/pubmed/28634355
http://dx.doi.org/10.1038/emi.2017.44
_version_ 1783251794052251648
author Hemida, Maged Gomaa
Alnaeem, Abdulmohsen
Chu, Daniel KW
Perera, Ranawaka APM
Chan, Samuel MS
Almathen, Faisal
Yau, Emily
Ng, Brian CY
Webby, Richard J
Poon, Leo LM
Peiris, Malik
author_facet Hemida, Maged Gomaa
Alnaeem, Abdulmohsen
Chu, Daniel KW
Perera, Ranawaka APM
Chan, Samuel MS
Almathen, Faisal
Yau, Emily
Ng, Brian CY
Webby, Richard J
Poon, Leo LM
Peiris, Malik
author_sort Hemida, Maged Gomaa
collection PubMed
description Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission.
format Online
Article
Text
id pubmed-5520318
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-55203182017-08-21 Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015 Hemida, Maged Gomaa Alnaeem, Abdulmohsen Chu, Daniel KW Perera, Ranawaka APM Chan, Samuel MS Almathen, Faisal Yau, Emily Ng, Brian CY Webby, Richard J Poon, Leo LM Peiris, Malik Emerg Microbes Infect Original Article Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission. Nature Publishing Group 2017-06 2017-06-21 /pmc/articles/PMC5520318/ /pubmed/28634355 http://dx.doi.org/10.1038/emi.2017.44 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Hemida, Maged Gomaa
Alnaeem, Abdulmohsen
Chu, Daniel KW
Perera, Ranawaka APM
Chan, Samuel MS
Almathen, Faisal
Yau, Emily
Ng, Brian CY
Webby, Richard J
Poon, Leo LM
Peiris, Malik
Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
title Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
title_full Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
title_fullStr Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
title_full_unstemmed Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
title_short Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015
title_sort longitudinal study of middle east respiratory syndrome coronavirus infection in dromedary camel herds in saudi arabia, 2014–2015
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520318/
https://www.ncbi.nlm.nih.gov/pubmed/28634355
http://dx.doi.org/10.1038/emi.2017.44
work_keys_str_mv AT hemidamagedgomaa longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT alnaeemabdulmohsen longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT chudanielkw longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT pereraranawakaapm longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT chansamuelms longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT almathenfaisal longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT yauemily longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT ngbriancy longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT webbyrichardj longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT poonleolm longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015
AT peirismalik longitudinalstudyofmiddleeastrespiratorysyndromecoronavirusinfectionindromedarycamelherdsinsaudiarabia20142015