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The thrombopoietin/MPL axis is activated in the Gata1(low) mouse model of myelofibrosis and is associated with a defective RPS14 signature

Myelofibrosis (MF) is characterized by hyperactivation of thrombopoietin (TPO) signaling, which induces a RPS14 deficiency that de-regulates GATA1 in megakaryocytes by hampering its mRNA translation. As mice carrying the hypomorphic Gata1(low) mutation, which reduces the levels of Gata1 mRNA in mega...

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Detalles Bibliográficos
Autores principales:	Zingariello, M, Sancillo, L, Martelli, F, Ciaffoni, F, Marra, M, Varricchio, L, Rana, R A, Zhao, C, Crispino, J D, Migliaccio, A R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520398/ https://www.ncbi.nlm.nih.gov/pubmed/28622305 http://dx.doi.org/10.1038/bcj.2017.51

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