Wnt signaling in triple-negative breast cancer

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregula...

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Detalles Bibliográficos
Autores principales: Pohl, SÖ-G, Brook, N, Agostino, M, Arfuso, F, Kumar, A P, Dharmarajan, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520491/
https://www.ncbi.nlm.nih.gov/pubmed/28368389
http://dx.doi.org/10.1038/oncsis.2017.14
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author Pohl, SÖ-G
Brook, N
Agostino, M
Arfuso, F
Kumar, A P
Dharmarajan, A
author_facet Pohl, SÖ-G
Brook, N
Agostino, M
Arfuso, F
Kumar, A P
Dharmarajan, A
author_sort Pohl, SÖ-G
collection PubMed
description Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.
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spelling pubmed-55204912017-07-28 Wnt signaling in triple-negative breast cancer Pohl, SÖ-G Brook, N Agostino, M Arfuso, F Kumar, A P Dharmarajan, A Oncogenesis Review Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease. Nature Publishing Group 2017-04 2017-04-03 /pmc/articles/PMC5520491/ /pubmed/28368389 http://dx.doi.org/10.1038/oncsis.2017.14 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review
Pohl, SÖ-G
Brook, N
Agostino, M
Arfuso, F
Kumar, A P
Dharmarajan, A
Wnt signaling in triple-negative breast cancer
title Wnt signaling in triple-negative breast cancer
title_full Wnt signaling in triple-negative breast cancer
title_fullStr Wnt signaling in triple-negative breast cancer
title_full_unstemmed Wnt signaling in triple-negative breast cancer
title_short Wnt signaling in triple-negative breast cancer
title_sort wnt signaling in triple-negative breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520491/
https://www.ncbi.nlm.nih.gov/pubmed/28368389
http://dx.doi.org/10.1038/oncsis.2017.14
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