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A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry

BACKGROUND AND AIMS: Limited registry studies are available on the use of anesthetic agents. This registry was conducted to evaluate emergence outcomes in Indian adult patients undergoing surgery with desflurane anesthesia. MATERIAL AND METHODS: This multicenter, prospective, non-interventional, obs...

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Autores principales: Kapoor, Mukul Chandra, Radhakrishnan, M., Ramesh, V. J., Murthy, H. S., Sharma, Dhirja, Gundappa, Parameswara, Das, Tanmoy, Wankhede, Ravi, Bhaskaran, K., Sengupta, Saiket, Patil, Rajendrasingh, Dey, Sibasish, Singh, Kuljinder, Moharana, Ashok K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520587/
https://www.ncbi.nlm.nih.gov/pubmed/28781440
http://dx.doi.org/10.4103/joacp.JOACP_350_16
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author Kapoor, Mukul Chandra
Radhakrishnan, M.
Ramesh, V. J.
Murthy, H. S.
Sharma, Dhirja
Gundappa, Parameswara
Das, Tanmoy
Wankhede, Ravi
Bhaskaran, K.
Sengupta, Saiket
Patil, Rajendrasingh
Dey, Sibasish
Singh, Kuljinder
Moharana, Ashok K
author_facet Kapoor, Mukul Chandra
Radhakrishnan, M.
Ramesh, V. J.
Murthy, H. S.
Sharma, Dhirja
Gundappa, Parameswara
Das, Tanmoy
Wankhede, Ravi
Bhaskaran, K.
Sengupta, Saiket
Patil, Rajendrasingh
Dey, Sibasish
Singh, Kuljinder
Moharana, Ashok K
author_sort Kapoor, Mukul Chandra
collection PubMed
description BACKGROUND AND AIMS: Limited registry studies are available on the use of anesthetic agents. This registry was conducted to evaluate emergence outcomes in Indian adult patients undergoing surgery with desflurane anesthesia. MATERIAL AND METHODS: This multicenter, prospective, non-interventional, observational study (Registry in India on Suprane Emergence [RISE] registry) included adult inpatients who received desflurane as general anesthetic for surgical procedure of ≥2 h. Patients were stratified by age into three groups: ≥18–40 years, ≥41–65 years, and >65 years. Data on patients’ demographics, practice, and usage pattern of medications were collected. The primary efficacy outcomes were time to extubation, time to response to verbal command, and time to orientation. RESULTS: Of 236 patients screened, 201 (≥18–40 years, n = 70; ≥41–65 years, n = 65; >65 years, n = 66) were enrolled in the study. Mean time to extubation observed in ≥18–40 years group was 7.2 ± 4.1 min, ≥41–65 years was 11.6 ± 8.99 min, and >65 years was 12.0 ± 10.5 min. Mean time to response to verbal command was 7.4 ± 4.3 min for ≥18–40 years, 10.9 ± 8.5 min for ≥41–65 years, and 10.0 ± 5.4 min for >65 years. Mean time to orientation was 13.0 ± 7.0 min for ≥18–40 years, 16.1 ± 12.0 min for ≥41–65 years, and 17.0 ± 8.6 min for >65 years. Incidence of nausea and retching/vomiting was observed in 8% of patients each in the postoperative period, and these complications were seen more in the >65 years age group. Overall, desflurane treatment maintained hemodynamic stability and no major airway events were reported. CONCLUSIONS: The RISE registry data suggest that desflurane-based anesthesia provides early recovery with stable hemodynamics without any airway adverse events, in a wide variety of surgical procedures.
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spelling pubmed-55205872017-08-04 A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry Kapoor, Mukul Chandra Radhakrishnan, M. Ramesh, V. J. Murthy, H. S. Sharma, Dhirja Gundappa, Parameswara Das, Tanmoy Wankhede, Ravi Bhaskaran, K. Sengupta, Saiket Patil, Rajendrasingh Dey, Sibasish Singh, Kuljinder Moharana, Ashok K J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND AIMS: Limited registry studies are available on the use of anesthetic agents. This registry was conducted to evaluate emergence outcomes in Indian adult patients undergoing surgery with desflurane anesthesia. MATERIAL AND METHODS: This multicenter, prospective, non-interventional, observational study (Registry in India on Suprane Emergence [RISE] registry) included adult inpatients who received desflurane as general anesthetic for surgical procedure of ≥2 h. Patients were stratified by age into three groups: ≥18–40 years, ≥41–65 years, and >65 years. Data on patients’ demographics, practice, and usage pattern of medications were collected. The primary efficacy outcomes were time to extubation, time to response to verbal command, and time to orientation. RESULTS: Of 236 patients screened, 201 (≥18–40 years, n = 70; ≥41–65 years, n = 65; >65 years, n = 66) were enrolled in the study. Mean time to extubation observed in ≥18–40 years group was 7.2 ± 4.1 min, ≥41–65 years was 11.6 ± 8.99 min, and >65 years was 12.0 ± 10.5 min. Mean time to response to verbal command was 7.4 ± 4.3 min for ≥18–40 years, 10.9 ± 8.5 min for ≥41–65 years, and 10.0 ± 5.4 min for >65 years. Mean time to orientation was 13.0 ± 7.0 min for ≥18–40 years, 16.1 ± 12.0 min for ≥41–65 years, and 17.0 ± 8.6 min for >65 years. Incidence of nausea and retching/vomiting was observed in 8% of patients each in the postoperative period, and these complications were seen more in the >65 years age group. Overall, desflurane treatment maintained hemodynamic stability and no major airway events were reported. CONCLUSIONS: The RISE registry data suggest that desflurane-based anesthesia provides early recovery with stable hemodynamics without any airway adverse events, in a wide variety of surgical procedures. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5520587/ /pubmed/28781440 http://dx.doi.org/10.4103/joacp.JOACP_350_16 Text en Copyright: © 2017 Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kapoor, Mukul Chandra
Radhakrishnan, M.
Ramesh, V. J.
Murthy, H. S.
Sharma, Dhirja
Gundappa, Parameswara
Das, Tanmoy
Wankhede, Ravi
Bhaskaran, K.
Sengupta, Saiket
Patil, Rajendrasingh
Dey, Sibasish
Singh, Kuljinder
Moharana, Ashok K
A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
title A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
title_full A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
title_fullStr A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
title_full_unstemmed A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
title_short A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
title_sort prospective observational study of the use of desflurane anesthesia in indian adult inpatients undergoing surgery: the registry in india on suprane emergence registry
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520587/
https://www.ncbi.nlm.nih.gov/pubmed/28781440
http://dx.doi.org/10.4103/joacp.JOACP_350_16
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