TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination

Tripartite motif-containing protein 45 (TRIM45) belongs to a large family of RING-finger-containing E3 ligases, which are highly expressed in the brain. However, little is known regarding the role of TRIM45 in cancer biology, especially in human glioma. Here, we report that TRIM45 expression is sign...

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Detalles Bibliográficos
Autores principales: Zhang, Jindong, Zhang, Chuanxia, Cui, Jun, Ou, Jiayu, Han, Jing, Qin, Yunfei, Zhi, Feng, Wang, Rong-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520693/
https://www.ncbi.nlm.nih.gov/pubmed/28542145
http://dx.doi.org/10.1038/cddis.2017.149

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