Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

Acute myeloid leukemia (AML) is a heterogeneous malignancy. Despite the advances in past decades, the clinical outcomes of AML patients remain poor. Leukemia stem cells (LSCs) is the major cause of the recurrence of AML even after aggressive treatment making, promoting development of LSC-targeted ag...

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Detalles Bibliográficos
Autores principales: Xu, Bing, Wang, Shiyun, Li, Rongwei, Chen, Kai, He, Lingli, Deng, Manman, Kannappan, Vinodh, Zha, Jie, Dong, Huijuan, Wang, Weiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520701/
https://www.ncbi.nlm.nih.gov/pubmed/28518151
http://dx.doi.org/10.1038/cddis.2017.176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520701/
https://www.ncbi.nlm.nih.gov/pubmed/28518151
http://dx.doi.org/10.1038/cddis.2017.176

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