Cargando…

Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

Acute myeloid leukemia (AML) is a heterogeneous malignancy. Despite the advances in past decades, the clinical outcomes of AML patients remain poor. Leukemia stem cells (LSCs) is the major cause of the recurrence of AML even after aggressive treatment making, promoting development of LSC-targeted ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Bing, Wang, Shiyun, Li, Rongwei, Chen, Kai, He, Lingli, Deng, Manman, Kannappan, Vinodh, Zha, Jie, Dong, Huijuan, Wang, Weiguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520701/ https://www.ncbi.nlm.nih.gov/pubmed/28518151 http://dx.doi.org/10.1038/cddis.2017.176

Ejemplares similares

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
por: Zha, Jie, et al.
Publicado: (2014)

Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents
por: Kannappan, Vinodh, et al.
Publicado: (2021)

The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
por: Tawari, Patricia Erebi, et al.
Publicado: (2015)

Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
por: Najlah, Mohammad, et al.
Publicado: (2019)

Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line
por: Butcher, Kate, et al.
Publicado: (2018)

Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners
por: Chiba, Tetsuhiro, et al.
Publicado: (2014)

Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models
por: Deng, Manman, et al.
Publicado: (2016)

Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo
por: Liu, Peng, et al.
Publicado: (2014)

Reply: Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
por: Liu, P, et al.
Publicado: (2013)

Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells
por: Wang, Zhipeng, et al.
Publicado: (2017)

Disulfiram/Copper induces antitumor activity against gastric cancer via the ROS/MAPK and NPL4 pathways
por: Liu, Yao, et al.
Publicado: (2022)

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
por: Liu, P, et al.
Publicado: (2012)

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
por: Ren, Xueying, et al.
Publicado: (2021)

Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
por: Yip, N C, et al.
Publicado: (2011)

Cell cycle specific radiosensitisation by the disulfiram and copper complex
por: Tesson, Mathias, et al.
Publicado: (2017)

Disulfiram‐copper activates chloride currents and induces apoptosis with tyrosine kinase in prostate cancer cells
por: Lei, Wei, et al.
Publicado: (2021)

Arsenic Trioxide and Venetoclax Synergize against AML Progenitors by ROS Induction and Inhibition of Nrf2 Activation
por: Hoang, Dinh Hoa, et al.
Publicado: (2022)

Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption
por: Zhao, Haijun, et al.
Publicado: (2016)

Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways
por: Li, Yiqiu, et al.
Publicado: (2020)

Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells
por: Chen, Ssu-Yu, et al.
Publicado: (2021)

Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
por: Kang, Xuejia, et al.
Publicado: (2023)

Targeting cancer stem cells by disulfiram and copper sensitizes radioresistant chondrosarcoma to radiation
por: Wang, Kun, et al.
Publicado: (2021)

Disulfiram, a Ferroptosis Inducer, Triggers Lysosomal Membrane Permeabilization by Up-Regulating ROS in Glioblastoma
por: Qiu, Chen, et al.
Publicado: (2020)

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
por: Wong, Chew Hooi, et al.
Publicado: (2010)

Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells
por: Kannappan, Vinodh, et al.
Publicado: (2017)

Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
por: Wong, Chew Hooi, et al.
Publicado: (2016)

Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma
por: Shah O’Brien, Priyanka, et al.
Publicado: (2019)

Disulfiram Induced Psychosis
por: Mohapatra, Satyakam, et al.
Publicado: (2017)

Disulfiram Treatment of Alcoholism
por: Anton, Raymond F.
Publicado: (1995)

Encephalopathy caused by disulfiram
por: Sant’Angelo, R., et al.
Publicado: (2021)

Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting
por: Ren, Liting, et al.
Publicado: (2020)

The Disulfiram/Copper Complex Induces Autophagic Cell Death in Colorectal Cancer by Targeting ULK1
por: Hu, Yeting, et al.
Publicado: (2021)

The Effect of Disulfiram and Copper on Cellular Viability, ER Stress and ALDH Expression of Human Meningioma Cells
por: Kao, Ying, et al.
Publicado: (2022)

Disulfiram/Copper Induces Immunogenic Cell Death and Enhances CD47 Blockade in Hepatocellular Carcinoma
por: Gao, Xingxing, et al.
Publicado: (2022)

Eradication of Measurable Residual Disease in AML: A Challenging Clinical Goal
por: Bernasconi, Paolo, et al.
Publicado: (2021)

Repurposing Disulfiram as an Antifungal Agent: Development of a New Disulfiram Vaginal Mucoadhesive Gel
por: Lajarin-Reinares, Maria, et al.
Publicado: (2023)

Disulfiram—Mitigating Unintended Effects
por: Grout, Martha M., et al.
Publicado: (2023)

Disulfiram: Mechanisms, Applications, and Challenges
por: Lanz, Jenna, et al.
Publicado: (2023)

Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: In Vitro Support for a Novel Drug Repurposing Strategy
por: Mandell, Jonathan B., et al.
Publicado: (2019)

Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML
por: Volk, Andrew, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_kmkf3a1b20uh46ao26ncald26k