Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cells

Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as a tumor suppressor and as an oncogene. Furthermo...

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Detalles Bibliográficos
Autores principales: Hilmarsdottir, Bylgja, Briem, Eirikur, Halldorsson, Skarphedinn, Kricker, Jennifer, Ingthorsson, Sævar, Gustafsdottir, Sigrun, Mælandsmo, Gunhild M, Magnusson, Magnus K, Gudjonsson, Thorarinn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520702/
https://www.ncbi.nlm.nih.gov/pubmed/28492548
http://dx.doi.org/10.1038/cddis.2017.177

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