Cargando…

CAF-secreted CXCL1 conferred radioresistance by regulating DNA damage response in a ROS-dependent manner in esophageal squamous cell carcinoma

Five-year survival rate of esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy is <20%. Our study aimed to investigate whether cancer-associated fibroblasts (CAFs), one major component of tumor microenvironment, were involved in tumor radioresistance in ESCC. By use of hu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hongfang, Yue, Jing, Jiang, Zhenzhen, Zhou, Rongjing, Xie, Ruifei, Xu, Yiping, Wu, Shixiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520705/ https://www.ncbi.nlm.nih.gov/pubmed/28518141 http://dx.doi.org/10.1038/cddis.2017.180

Ejemplares similares

Fractionated irradiation-induced EMT-like phenotype conferred radioresistance in esophageal squamous cell carcinoma
por: Zhang, Hongfang, et al.
Publicado: (2016)

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation
por: Zhang, Hongfang, et al.
Publicado: (2015)

Single-cell RNA-seq of esophageal squamous cell carcinoma cell line with fractionated irradiation reveals radioresistant gene expression patterns
por: Yang, Ling, et al.
Publicado: (2019)

CBX4 contributes to radioresistance by regulating autophagic activity in esophageal squamous cell carcinoma
por: Zhu, Hongcheng, et al.
Publicado: (2022)

A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
por: Ma, Li, et al.
Publicado: (2023)

Icotinib With Concurrent Radiotherapy vs Radiotherapy Alone in Older Adults With Unresectable Esophageal Squamous Cell Carcinoma: A Phase II Randomized Clinical Trial
por: Luo, Honglei, et al.
Publicado: (2020)

RIG-I Promotes Tumorigenesis and Confers Radioresistance of Esophageal Squamous Cell Carcinoma by Regulating DUSP6
por: Li, Lu, et al.
Publicado: (2023)

Hypoxic Radioresistance: Can ROS Be the Key to Overcome It?
por: Wang, Hui, et al.
Publicado: (2019)

Downregulation of H19 decreases the radioresistance in esophageal squamous cell carcinoma cells
por: Luo, Wenguang, et al.
Publicado: (2019)

Identification and Functional Validation of Radioresistance-Related Genes AHNAK2 and EVPL in Esophageal Squamous Cell Carcinoma by Exome and Transcriptome Sequencing Analyses
por: Hou, Qiang, et al.
Publicado: (2021)

Polymerase iota (POLI) confers radioresistance of esophageal squamous cell carcinoma by regulating RAD51 stability and facilitating homologous recombination
por: Li, Xiaoqing, et al.
Publicado: (2023)

Identification of critical radioresistance genes in esophageal squamous cell carcinoma by whole-exome sequencing
por: Chen, Zhiming, et al.
Publicado: (2020)

Identification of a three-gene prognostic signature for radioresistant esophageal squamous cell carcinoma
por: Wang, Xiao-Yan, et al.
Publicado: (2023)

Prior anti-CAFs break down the CAFs barrier and improve accumulation of docetaxel micelles in tumor
por: Pang, Ning, et al.
Publicado: (2018)

Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair
por: Liu, Hai, et al.
Publicado: (2015)

Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma
por: Zhao, Yuanyuan, et al.
Publicado: (2018)

CTCF-silenced miR-137 contributes to EMT and radioresistance in esophageal squamous cell carcinoma
por: Xu, Shuwen, et al.
Publicado: (2021)

FMS-Related Tyrosine Kinase 3 Ligand Promotes Radioresistance in Esophageal Squamous Cell Carcinoma
por: Zhu, Zuoquan, et al.
Publicado: (2021)

REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2
por: Gu, Cheng, et al.
Publicado: (2019)

MUC1 confers radioresistance in head and neck squamous cell carcinoma (HNSCC) cells
por: Huang, Tian-qiao, et al.
Publicado: (2020)

The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance
por: Du, Yarong, et al.
Publicado: (2020)

RMP promotes the proliferation and radioresistance of esophageal carcinoma
por: Chen, Shaomu, et al.
Publicado: (2019)

Reduced hyaluronan cross-linking induces breast cancer malignancy in a CAF-dependent manner
por: Zhang, Guoliang, et al.
Publicado: (2021)

CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair
por: Zhou, Yuzhen, et al.
Publicado: (2018)

The expression of p‐p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance
por: Wang, Zhe, et al.
Publicado: (2019)

Mesenchymal stem cells over-expressing cxcl12 enhance the radioresistance of the small intestine
por: Chang, Pengyu, et al.
Publicado: (2018)

Elevation of CXCL1 indicates poor prognosis and radioresistance by inducing mesenchymal transition in glioblastoma
por: Alafate, Wahafu, et al.
Publicado: (2020)

STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma
por: Jiang, Kan, et al.
Publicado: (2023)

Primary impact of Gli1 on radioresistance in esophageal cancer
por: Yao, Fei, et al.
Publicado: (2019)

CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis
por: Uchi, Yusuke, et al.
Publicado: (2016)

The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma
por: Wu, Xianxian, et al.
Publicado: (2021)

Sp1-mediated transcriptional activation of miR-205 promotes radioresistance in esophageal squamous cell carcinoma
por: Pan, Fei, et al.
Publicado: (2016)

Acid ceramidase confers radioresistance to glioblastoma cells
por: Doan, Ninh B., et al.
Publicado: (2017)

RAD18 confers radioresistance of esophagus squamous cell carcinoma through regulating p‐DNA‐PKcs
por: Li, Xiaoqing, et al.
Publicado: (2022)

BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage
por: Storch, Katja, et al.
Publicado: (2016)

The Secret of Good Manners
Publicado: (1881)

High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy
por: Ma, Hongbing, et al.
Publicado: (2019)

IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma
por: Zang, Chunbao, et al.
Publicado: (2017)

SIX1 overexpression predicts poor prognosis and induces radioresistance through AKT signaling in esophageal squamous cell carcinoma
por: He, Zheng, et al.
Publicado: (2017)

Population and single-cell transcriptome analyses reveal diverse transcriptional changes associated with radioresistance in esophageal squamous cell carcinoma
por: Wu, Hongjin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_mg34rfn9poa72imf7vr937hm7g