TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy

Thioredoxin-interacting protein (TXNIP) is involved in oxidative stress and apoptosis in diabetic retinopathy. However, the role of TXNIP in the removal of damaged mitochondria (MT) via mitophagy, a process of macroautophagy, remains unexplored. Here we investigate the associated cellular and molecu...

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Detalles Bibliográficos
Autores principales: Devi, Takhellambam Swornalata, Somayajulu, Mallika, Kowluru, Renu Anjan, Singh, Lalit Pukhrambam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520711/
https://www.ncbi.nlm.nih.gov/pubmed/28492550
http://dx.doi.org/10.1038/cddis.2017.190

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