A role for TSPO in mitochondrial Ca(2+) homeostasis and redox stress signaling

The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondria by limiting PARK2-mediated mitochondrial ubiquit...

Descripción completa

Detalles Bibliográficos
Autores principales: Gatliff, Jemma, East, Daniel A, Singh, Aarti, Alvarez, Maria Soledad, Frison, Michele, Matic, Ivana, Ferraina, Caterina, Sampson, Natalie, Turkheimer, Federico, Campanella, Michelangelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520880/
https://www.ncbi.nlm.nih.gov/pubmed/28640253
http://dx.doi.org/10.1038/cddis.2017.186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520880/
https://www.ncbi.nlm.nih.gov/pubmed/28640253
http://dx.doi.org/10.1038/cddis.2017.186

Ejemplares similares