E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis
Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis. E2F1 is aberrantly expressed in g...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520882/ https://www.ncbi.nlm.nih.gov/pubmed/28569791 http://dx.doi.org/10.1038/cddis.2017.205 |
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author | Xu, Tong-Peng Wang, Yan-Fen Xiong, Wei-Liang Ma, Pei Wang, Wen-Yu Chen, Wen-Ming Huang, Ming-De Xia, Rui Wang, Rong Zhang, Er-Bao Liu, Yan-Wen De, Wei Shu, Yong-Qian |
author_facet | Xu, Tong-Peng Wang, Yan-Fen Xiong, Wei-Liang Ma, Pei Wang, Wen-Yu Chen, Wen-Ming Huang, Ming-De Xia, Rui Wang, Rong Zhang, Er-Bao Liu, Yan-Wen De, Wei Shu, Yong-Qian |
author_sort | Xu, Tong-Peng |
collection | PubMed |
description | Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis. E2F1 is aberrantly expressed in gastric cancer (GC), and biology functions of E2F1 in GC are controversial. The biological characteristics of E2F1 and correlation between E2F1 and lncRNAs in GC remain to be found. In this study, integrated analysis revealed that E2F1 expression was significantly increased in GC cases and its expression was positively correlated with the poor pathologic stage, large tumor size and poor prognosis. Forced E2F1 expression promotes proliferation, whereas loss of E2F1 function decreased cell proliferation by blocking of cell cycle in GC cells. Mechanistic analyses indicated that E2F1 accelerates GC growth partly through induces TINCR transcription. TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of GC cells. Together, our findings suggest that E2F1/TINCR/STAU1/CDKN2B signaling axis contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease. |
format | Online Article Text |
id | pubmed-5520882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55208822017-07-27 E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis Xu, Tong-Peng Wang, Yan-Fen Xiong, Wei-Liang Ma, Pei Wang, Wen-Yu Chen, Wen-Ming Huang, Ming-De Xia, Rui Wang, Rong Zhang, Er-Bao Liu, Yan-Wen De, Wei Shu, Yong-Qian Cell Death Dis Original Article Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis. E2F1 is aberrantly expressed in gastric cancer (GC), and biology functions of E2F1 in GC are controversial. The biological characteristics of E2F1 and correlation between E2F1 and lncRNAs in GC remain to be found. In this study, integrated analysis revealed that E2F1 expression was significantly increased in GC cases and its expression was positively correlated with the poor pathologic stage, large tumor size and poor prognosis. Forced E2F1 expression promotes proliferation, whereas loss of E2F1 function decreased cell proliferation by blocking of cell cycle in GC cells. Mechanistic analyses indicated that E2F1 accelerates GC growth partly through induces TINCR transcription. TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of GC cells. Together, our findings suggest that E2F1/TINCR/STAU1/CDKN2B signaling axis contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease. Nature Publishing Group 2017-06 2017-06-01 /pmc/articles/PMC5520882/ /pubmed/28569791 http://dx.doi.org/10.1038/cddis.2017.205 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Xu, Tong-Peng Wang, Yan-Fen Xiong, Wei-Liang Ma, Pei Wang, Wen-Yu Chen, Wen-Ming Huang, Ming-De Xia, Rui Wang, Rong Zhang, Er-Bao Liu, Yan-Wen De, Wei Shu, Yong-Qian E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis |
title | E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis |
title_full | E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis |
title_fullStr | E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis |
title_full_unstemmed | E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis |
title_short | E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis |
title_sort | e2f1 induces tincr transcriptional activity and accelerates gastric cancer progression via activation of tincr/stau1/cdkn2b signaling axis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520882/ https://www.ncbi.nlm.nih.gov/pubmed/28569791 http://dx.doi.org/10.1038/cddis.2017.205 |
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