E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis

Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis. E2F1 is aberrantly expressed in g...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Tong-Peng, Wang, Yan-Fen, Xiong, Wei-Liang, Ma, Pei, Wang, Wen-Yu, Chen, Wen-Ming, Huang, Ming-De, Xia, Rui, Wang, Rong, Zhang, Er-Bao, Liu, Yan-Wen, De, Wei, Shu, Yong-Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520882/
https://www.ncbi.nlm.nih.gov/pubmed/28569791
http://dx.doi.org/10.1038/cddis.2017.205
_version_ 1783251885422018560
author Xu, Tong-Peng
Wang, Yan-Fen
Xiong, Wei-Liang
Ma, Pei
Wang, Wen-Yu
Chen, Wen-Ming
Huang, Ming-De
Xia, Rui
Wang, Rong
Zhang, Er-Bao
Liu, Yan-Wen
De, Wei
Shu, Yong-Qian
author_facet Xu, Tong-Peng
Wang, Yan-Fen
Xiong, Wei-Liang
Ma, Pei
Wang, Wen-Yu
Chen, Wen-Ming
Huang, Ming-De
Xia, Rui
Wang, Rong
Zhang, Er-Bao
Liu, Yan-Wen
De, Wei
Shu, Yong-Qian
author_sort Xu, Tong-Peng
collection PubMed
description Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis. E2F1 is aberrantly expressed in gastric cancer (GC), and biology functions of E2F1 in GC are controversial. The biological characteristics of E2F1 and correlation between E2F1 and lncRNAs in GC remain to be found. In this study, integrated analysis revealed that E2F1 expression was significantly increased in GC cases and its expression was positively correlated with the poor pathologic stage, large tumor size and poor prognosis. Forced E2F1 expression promotes proliferation, whereas loss of E2F1 function decreased cell proliferation by blocking of cell cycle in GC cells. Mechanistic analyses indicated that E2F1 accelerates GC growth partly through induces TINCR transcription. TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of GC cells. Together, our findings suggest that E2F1/TINCR/STAU1/CDKN2B signaling axis contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease.
format Online
Article
Text
id pubmed-5520882
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-55208822017-07-27 E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis Xu, Tong-Peng Wang, Yan-Fen Xiong, Wei-Liang Ma, Pei Wang, Wen-Yu Chen, Wen-Ming Huang, Ming-De Xia, Rui Wang, Rong Zhang, Er-Bao Liu, Yan-Wen De, Wei Shu, Yong-Qian Cell Death Dis Original Article Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis. E2F1 is aberrantly expressed in gastric cancer (GC), and biology functions of E2F1 in GC are controversial. The biological characteristics of E2F1 and correlation between E2F1 and lncRNAs in GC remain to be found. In this study, integrated analysis revealed that E2F1 expression was significantly increased in GC cases and its expression was positively correlated with the poor pathologic stage, large tumor size and poor prognosis. Forced E2F1 expression promotes proliferation, whereas loss of E2F1 function decreased cell proliferation by blocking of cell cycle in GC cells. Mechanistic analyses indicated that E2F1 accelerates GC growth partly through induces TINCR transcription. TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of GC cells. Together, our findings suggest that E2F1/TINCR/STAU1/CDKN2B signaling axis contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease. Nature Publishing Group 2017-06 2017-06-01 /pmc/articles/PMC5520882/ /pubmed/28569791 http://dx.doi.org/10.1038/cddis.2017.205 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Xu, Tong-Peng
Wang, Yan-Fen
Xiong, Wei-Liang
Ma, Pei
Wang, Wen-Yu
Chen, Wen-Ming
Huang, Ming-De
Xia, Rui
Wang, Rong
Zhang, Er-Bao
Liu, Yan-Wen
De, Wei
Shu, Yong-Qian
E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis
title E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis
title_full E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis
title_fullStr E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis
title_full_unstemmed E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis
title_short E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis
title_sort e2f1 induces tincr transcriptional activity and accelerates gastric cancer progression via activation of tincr/stau1/cdkn2b signaling axis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520882/
https://www.ncbi.nlm.nih.gov/pubmed/28569791
http://dx.doi.org/10.1038/cddis.2017.205
work_keys_str_mv AT xutongpeng e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT wangyanfen e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT xiongweiliang e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT mapei e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT wangwenyu e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT chenwenming e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT huangmingde e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT xiarui e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT wangrong e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT zhangerbao e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT liuyanwen e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT dewei e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis
AT shuyongqian e2f1inducestincrtranscriptionalactivityandacceleratesgastriccancerprogressionviaactivationoftincrstau1cdkn2bsignalingaxis