Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viabilit...

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Detalles Bibliográficos
Autores principales: Cheteh, Emarndeena H, Augsten, Martin, Rundqvist, Helene, Bianchi, Julie, Sarne, Victoria, Egevad, Lars, Bykov, Vladimir JN, Östman, Arne, Wiman, Klas G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520886/
https://www.ncbi.nlm.nih.gov/pubmed/28569790
http://dx.doi.org/10.1038/cddis.2017.225

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