Cargando…

Precision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study

The aim of this study was to design a road map for personalizing cancer therapy in hepatocellular carcinoma (HCC) by using molecular pattern diagnostics. As an exploratory study, we investigated molecular patterns of tissues of two tumors from individual HCC patients, which in previous experiments h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agarwal, Rahul, Cao, Yuan, Hoffmeier, Klaus, Krezdorn, Nicolas, Jost, Lukas, Meisel, Alejandro Rodriguez, Jüngling, Ruth, Dituri, Francesco, Mancarella, Serena, Rotter, Björn, Winter, Peter, Giannelli, Gianluigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520889/ https://www.ncbi.nlm.nih.gov/pubmed/28594404 http://dx.doi.org/10.1038/cddis.2017.229

Ejemplares similares

NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC
por: Cao, Yuan, et al.
Publicado: (2017)

The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
por: Dituri, Francesco, et al.
Publicado: (2019)

Impaired Anti-Tumor T cell Response in Hepatocellular Carcinoma
por: Chaoul, Nada, et al.
Publicado: (2020)

Proteoglycans in Cancer: Friends or Enemies? A Special Focus on Hepatocellular Carcinoma
por: Dituri, Francesco, et al.
Publicado: (2022)

Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC
por: Modica, Teresa Maria Elisa, et al.
Publicado: (2019)

Validation of Hepatocellular Carcinoma Experimental Models for TGF-β Promoting Tumor Progression
por: Mancarella, Serena, et al.
Publicado: (2019)

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
por: Caja, Laia, et al.
Publicado: (2018)

Roles of Tumor Microenvironment in Hepatocelluar Carcinoma
por: Seo, Haeng R.
Publicado: (2015)

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression
por: Rani, Bhavna, et al.
Publicado: (2018)

Direct and Indirect Effect of TGFβ on Treg Transendothelial Recruitment in HCC Tissue Microenvironment
por: Dituri, Francesco, et al.
Publicado: (2021)

Proteoglycan-4 is correlated with longer survival in HCC patients and enhances sorafenib and regorafenib effectiveness via CD44 in vitro
por: Dituri, Francesco, et al.
Publicado: (2020)

The Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression
por: Mancarella, Serena, et al.
Publicado: (2022)

Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis
por: Mancarella, Serena, et al.
Publicado: (2020)

Deep Super-SAGE transcriptomic analysis of cold acclimation in lentil (Lens culinaris Medik.)
por: Barrios, Abel, et al.
Publicado: (2017)

Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition
por: Mancarella, Serena, et al.
Publicado: (2022)

In planta Identification of Putative Pathogenicity Factors from the Chickpea Pathogen Ascochyta rabiei by De novo Transcriptome Sequencing Using RNA-Seq and Massive Analysis of cDNA Ends
por: Fondevilla, Sara, et al.
Publicado: (2015)

Bulked segregant transcriptome analysis in pea identifies key expression markers for resistance to Peyronellaea pinodes
por: Fondevilla, Sara, et al.
Publicado: (2022)

Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT
por: Zhou, Hong-Hao, et al.
Publicado: (2016)

Hepatic Artery Thrombosis: A Rare Complication of Microwave Ablation in Hepatocelluar Carcinoma
por: Aujla, Amreet K, et al.
Publicado: (2020)

Identification of novel small ncRNAs in pollen of tomato
por: Bokszczanin, Kamila Lucia, et al.
Publicado: (2015)

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
por: Centonze, Matteo, et al.
Publicado: (2023)

Combined effect of socioeconomic status, viral hepatitis, and lifestyles on hepatocelluar carcinoma risk in Korea
por: Yun, E H, et al.
Publicado: (2010)

MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma
por: Huang, Jia-Yuan, et al.
Publicado: (2015)

Prognostic nomograms for patients with resectable hepatocelluar carcinoma incorporating systemic inflammation and tumor characteristics
por: Shen, Junyi, et al.
Publicado: (2016)

PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors
por: Dituri, Francesco, et al.
Publicado: (2011)

Transforming Growth Factor-β Promotes Morphomechanical Effects Involved in Epithelial to Mesenchymal Transition in Living Hepatocellular Carcinoma
por: Cascione, Mariafrancesca, et al.
Publicado: (2018)

Laminin-332 γ2 Monomeric Chain Promotes Adhesion and Migration of Hepatocellular Carcinoma Cells
por: Scialpi, Rosanna, et al.
Publicado: (2023)

Correction: Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
por: Centonze, Matteo, et al.
Publicado: (2023)

Dual 3’Seq using deepSuperSAGE uncovers transcriptomes of interacting Salmonella enterica Typhimurium and human host cells
por: Afonso-Grunz, Fabian, et al.
Publicado: (2015)

DLEC1 Expression Is Modulated by Epigenetic Modifications in Hepatocelluar Carcinoma Cells: Role of HBx Genotypes
por: Niu, Dandan, et al.
Publicado: (2010)

Safety and Efficacy of Liver-Directed Radiotherapy in Combination With Lenvatinib for Hepatocelluar Carcinoma With Macroscopic Tumor Thrombosis
por: Yu, Jeong Il, et al.
Publicado: (2022)

SuperSAGE analysis of the Nicotiana attenuata transcriptome after fatty acid-amino acid elicitation (FAC): identification of early mediators of insect responses
por: Gilardoni, Paola A, et al.
Publicado: (2010)

Association between metabolic abnormalities and HBV related hepatocelluar carcinoma in Chinese: A cross-sectional study
por: Zhao, Jinyan, et al.
Publicado: (2011)

Suppression of E-cadherin Mediates Gallotannin Induced Apoptosis in Hep G2 Hepatocelluar Carcinoma Cells
por: Han, Hee Jeong, et al.
Publicado: (2014)

Predicting surgical site infections using a novel nomogram in patients with hepatocelluar carcinoma undergoing hepatectomy
por: Tang, Tian-Yu, et al.
Publicado: (2019)

Lathyrus sativus transcriptome resistance response to Ascochyta lathyri investigated by deepSuperSAGE analysis
por: Almeida, Nuno F., et al.
Publicado: (2015)

Upregulation of the oestrogen target gene SIX1 is associated with higher growth speed and decreased survival in HCV-positive women with hepatocellular carcinoma
por: Critelli, Rosina Maria, et al.
Publicado: (2022)

Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis
por: Matsui, Osamu, et al.
Publicado: (2011)

The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis
por: Shen, Junyi, et al.
Publicado: (2018)

Dosimetric impact of contrast-enhanced 4d computed tomography for stereotactic body radiation therapy of hepatocelluar carcinoma
por: Kamal, Rose, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ht50inure14cdqoftdmkoa6tdp