The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth

HIF-1 is associated with poor prognoses and therapeutic resistance in cancer patients. We previously developed a novel hypoxia-inducible factor (HIF)-1 inhibitor, IDF-11774, a clinical candidate for cancer therapy. We also reported that IDF-1174 inhibited HSP70 chaperone activity and suppressed accu...

Descripción completa

Detalles Bibliográficos
Autores principales: Ban, Hyun Seung, Kim, Bo-Kyung, Lee, Hongsub, Kim, Hwan Mook, Harmalkar, Dipesh, Nam, Miso, Park, Song-Kyu, Lee, Kiho, Park, Joon-Tae, Kim, Inhyub, Lee, Kyeong, Hwang, Geum-Sook, Won, Misun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520894/
https://www.ncbi.nlm.nih.gov/pubmed/28569777
http://dx.doi.org/10.1038/cddis.2017.235

Ejemplares similares

Ejemplares similares