HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination

Integrase inhibitors are a class of antiretroviral drugs used for the treatment of AIDS that target HIV integrase, an enzyme responsible for integration of viral cDNA into host genome. RAG1, a critical enzyme involved in V(D)J recombination exhibits structural similarity to HIV integrase. We find th...

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Detalles Bibliográficos
Autores principales: Nishana, Mayilaadumveettil, Nilavar, Namrata M, Kumari, Rupa, Pandey, Monica, Raghavan, Sathees C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520896/
https://www.ncbi.nlm.nih.gov/pubmed/28569776
http://dx.doi.org/10.1038/cddis.2017.237

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