Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells

The lysine-specific demethylase 1 (LSD1) is overexpressed in several cancers including rhabdomyosarcoma (RMS). However, little is yet known about whether or not LSD1 may serve as therapeutic target in RMS. We therefore investigated the potential of LSD1 inhibitors alone or in combination with other...

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Detalles Bibliográficos
Autores principales: Haydn, Tinka, Metzger, Eric, Schuele, Roland, Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520898/
https://www.ncbi.nlm.nih.gov/pubmed/28617441
http://dx.doi.org/10.1038/cddis.2017.239

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