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Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling
Limited benefits and clinical utility of temozolomide (TMZ) for glioblastoma (GB) are frequently compromised by the development of acquired drug resistance. Overcoming TMZ resistance and uncovering the underlying mechanisms are challenges faced during GB chemotherapy. In this study, we reported that...
Autores principales: | Zeng, Huijun, Yang, Zhao, Xu, Ningbo, Liu, Boyang, Fu, Zhao, Lian, Changlin, Guo, Hongbo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520906/ https://www.ncbi.nlm.nih.gov/pubmed/28617438 http://dx.doi.org/10.1038/cddis.2017.248 |
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