Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells

Squamous cell carcinoma (SCC) or epidermoid cancer is a frequent and aggressive malignancy. However in apparent paradox it retains the squamous differentiation phenotype except for very dysplastic lesions. We have shown that cell cycle stress in normal epidermal keratinocytes triggers a squamous dif...

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Detalles Bibliográficos
Autores principales: Alonso-Lecue, Pilar, de Pedro, Isabel, Coulon, Vincent, Molinuevo, Rut, Lorz, Corina, Segrelles, Carmen, Ceballos, Laura, López-Aventín, Daniel, García-Valtuille, Ana, Bernal, José M, Mazorra, Francisco, Pujol, Ramón M, Paramio, Jesús, Ramón Sanz, J, Freije, Ana, Toll, Agustí, Gandarillas, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520915/
https://www.ncbi.nlm.nih.gov/pubmed/28661481
http://dx.doi.org/10.1038/cddis.2017.259

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