Bilirubin neurotoxicity is associated with proteasome inhibition

The molecular mechanism underlying bilirubin neurotoxicity remains obscure. Ubiquitin–proteasome system-mediated proteolysis is pivotal to virtually all cellular processes and cell survival. Here we report for the first time that bilirubin at a clinically relevant elevated level impairs proteasomal...

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Detalles Bibliográficos
Autores principales: Huang, Hongbiao, Guo, Mingxing, Liu, Ningning, Zhao, Chong, Chen, Haoyu, Wang, Xiaoli, Liao, Siyan, Zhou, Ping, Liao, Yuning, Chen, Xin, Lan, Xiaoying, Chen, Jinghong, Xu, Dacai, Li, Xiaofen, Shi, Xianping, Yu, Li, Nie, Yuqiang, Wang, Xuejun, Zhang, Chang-E, Liu, Jinbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520929/
https://www.ncbi.nlm.nih.gov/pubmed/28617443
http://dx.doi.org/10.1038/cddis.2017.274

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