Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis

Chemotherapy-induced thrombocytopenia is a common bleeding risk in cancer patients and limits chemotherapy dose and frequency. Recent data from mouse and human platelets revealed that activation of protein kinase A/G (PKA/PKG) not only inhibited thrombin/convulxin-induced platelet activation but als...

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Detalles Bibliográficos
Autores principales: Rukoyatkina, Natalia, Butt, Elke, Subramanian, Hariharan, Nikolaev, Viacheslav O, Mindukshev, Igor, Walter, Ulrich, Gambaryan, Stepan, Benz, Peter M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520940/
https://www.ncbi.nlm.nih.gov/pubmed/28661475
http://dx.doi.org/10.1038/cddis.2017.290

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