Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Necroptosis contributes to the pathophysiology of several inflammatory, infectious and degenerative disorders. TNF-induced necroptosis involves activation of the receptor-interacting protein kinases 1 and 3 (RIPK1/3) in a necrosome complex, eventually leading to the phosphorylation and relocation of...

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Detalles Bibliográficos
Autores principales: Martens, Sofie, Jeong, Manhyung, Tonnus, Wulf, Feldmann, Friederike, Hofmans, Sam, Goossens, Vera, Takahashi, Nozomi, Bräsen, Jan Hinrich, Lee, Eun-Woo, Van der Veken, Pieter, Joossens, Jurgen, Augustyns, Koen, Fulda, Simone, Linkermann, Andreas, Song, Jaewhan, Vandenabeele, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520944/
https://www.ncbi.nlm.nih.gov/pubmed/28661484
http://dx.doi.org/10.1038/cddis.2017.298

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