Cargando…
Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342)
BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called ‘scratching’, has been proposed to positively affect the chance of implantation after embryo transf...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521151/ https://www.ncbi.nlm.nih.gov/pubmed/28732531 http://dx.doi.org/10.1186/s12905-017-0378-y |
| _version_ | 1783251927281172480 |
|---|---|
| author | van Hoogenhuijze, N. E. Torrance, H. L. Mol, F. Laven, J. S. E. Scheenjes, E. Traas, M. A. F. Janssen, C. Cohlen, B. Teklenburg, G. de Bruin, J. P. van Oppenraaij, R. Maas, J. W. M. Moll, E. Fleischer, K. van Hooff, M. H. de Koning, C. Cantineau, A. Lambalk, C. B. Verberg, M. Nijs, M. Manger, A. P. van Rumste, M. van der Voet, L. F. Preys-Bosman, A. Visser, J. Brinkhuis, E. den Hartog, J. E. Sluijmer, A. Jansen, F. W. Hermes, W. Bandell, M. L. Pelinck, M. J. van Disseldorp, J. van Wely, M. Smeenk, J. Pieterse, Q. D. Boxmeer, J.C. Groenewoud, E.R. Eijkemans, M. J. C. Kasius, J. C. Broekmans, F. J. M. |
| author_facet | van Hoogenhuijze, N. E. Torrance, H. L. Mol, F. Laven, J. S. E. Scheenjes, E. Traas, M. A. F. Janssen, C. Cohlen, B. Teklenburg, G. de Bruin, J. P. van Oppenraaij, R. Maas, J. W. M. Moll, E. Fleischer, K. van Hooff, M. H. de Koning, C. Cantineau, A. Lambalk, C. B. Verberg, M. Nijs, M. Manger, A. P. van Rumste, M. van der Voet, L. F. Preys-Bosman, A. Visser, J. Brinkhuis, E. den Hartog, J. E. Sluijmer, A. Jansen, F. W. Hermes, W. Bandell, M. L. Pelinck, M. J. van Disseldorp, J. van Wely, M. Smeenk, J. Pieterse, Q. D. Boxmeer, J.C. Groenewoud, E.R. Eijkemans, M. J. C. Kasius, J. C. Broekmans, F. J. M. |
| author_sort | van Hoogenhuijze, N. E. |
| collection | PubMed |
| description | BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called ‘scratching’, has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. METHOD: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2(nd) fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2(nd) IVF/ICSI cycle and over 12 months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. DISCUSSION: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. TRIAL REGISTRATION: NTR 5342, registered July 31(st), 2015. PROTOCOL VERSION: Version 4.10, January 4th, 2017. |
| format | Online Article Text |
| id | pubmed-5521151 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55211512017-07-21 Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342) van Hoogenhuijze, N. E. Torrance, H. L. Mol, F. Laven, J. S. E. Scheenjes, E. Traas, M. A. F. Janssen, C. Cohlen, B. Teklenburg, G. de Bruin, J. P. van Oppenraaij, R. Maas, J. W. M. Moll, E. Fleischer, K. van Hooff, M. H. de Koning, C. Cantineau, A. Lambalk, C. B. Verberg, M. Nijs, M. Manger, A. P. van Rumste, M. van der Voet, L. F. Preys-Bosman, A. Visser, J. Brinkhuis, E. den Hartog, J. E. Sluijmer, A. Jansen, F. W. Hermes, W. Bandell, M. L. Pelinck, M. J. van Disseldorp, J. van Wely, M. Smeenk, J. Pieterse, Q. D. Boxmeer, J.C. Groenewoud, E.R. Eijkemans, M. J. C. Kasius, J. C. Broekmans, F. J. M. BMC Womens Health Study Protocol BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called ‘scratching’, has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. METHOD: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2(nd) fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2(nd) IVF/ICSI cycle and over 12 months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. DISCUSSION: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. TRIAL REGISTRATION: NTR 5342, registered July 31(st), 2015. PROTOCOL VERSION: Version 4.10, January 4th, 2017. BioMed Central 2017-07-21 /pmc/articles/PMC5521151/ /pubmed/28732531 http://dx.doi.org/10.1186/s12905-017-0378-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Study Protocol van Hoogenhuijze, N. E. Torrance, H. L. Mol, F. Laven, J. S. E. Scheenjes, E. Traas, M. A. F. Janssen, C. Cohlen, B. Teklenburg, G. de Bruin, J. P. van Oppenraaij, R. Maas, J. W. M. Moll, E. Fleischer, K. van Hooff, M. H. de Koning, C. Cantineau, A. Lambalk, C. B. Verberg, M. Nijs, M. Manger, A. P. van Rumste, M. van der Voet, L. F. Preys-Bosman, A. Visser, J. Brinkhuis, E. den Hartog, J. E. Sluijmer, A. Jansen, F. W. Hermes, W. Bandell, M. L. Pelinck, M. J. van Disseldorp, J. van Wely, M. Smeenk, J. Pieterse, Q. D. Boxmeer, J.C. Groenewoud, E.R. Eijkemans, M. J. C. Kasius, J. C. Broekmans, F. J. M. Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342) |
| title | Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342) |
| title_full | Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342) |
| title_fullStr | Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342) |
| title_full_unstemmed | Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342) |
| title_short | Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342) |
| title_sort | endometrial scratching in women with implantation failure after a first ivf/icsi cycle; does it lead to a higher live birth rate? the scratch study: a randomized controlled trial (ntr 5342) |
| topic | Study Protocol |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521151/ https://www.ncbi.nlm.nih.gov/pubmed/28732531 http://dx.doi.org/10.1186/s12905-017-0378-y |
| work_keys_str_mv | AT vanhoogenhuijzene endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT torrancehl endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT molf endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT lavenjse endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT scheenjese endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT traasmaf endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT janssenc endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT cohlenb endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT teklenburgg endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT debruinjp endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT vanoppenraaijr endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT maasjwm endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT molle endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT fleischerk endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT vanhooffmh endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT dekoningc endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT cantineaua endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT lambalkcb endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT verbergm endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT nijsm endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT mangerap endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT vanrumstem endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT vandervoetlf endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT preysbosmana endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT visserj endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT brinkhuise endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT denhartogje endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT sluijmera endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT jansenfw endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT hermesw endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT bandellml endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT pelinckmj endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT vandisseldorpj endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT vanwelym endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT smeenkj endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT pieterseqd endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT boxmeerjc endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT groenewouder endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT eijkemansmjc endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT kasiusjc endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 AT broekmansfjm endometrialscratchinginwomenwithimplantationfailureafterafirstivficsicycledoesitleadtoahigherlivebirthratethescratchstudyarandomizedcontrolledtrialntr5342 |