Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles

Bimodal nanoprobes comprising both magnetic and optical functionalities have been prepared via a sequential two-step process. Firstly, magnetite nanoparticles (MNPs) with well-defined cubic shape and an average dimension of 80 nm were produced by hydrolysis of iron sulfate and were then surface modi...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinheiro, Paula C., Daniel-da-Silva, Ana L., Tavares, Daniela S., Calatayud, M. Pilar, Goya, Gerardo F., Trindade, Tito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521243/
https://www.ncbi.nlm.nih.gov/pubmed/28811431
http://dx.doi.org/10.3390/ma6083213
Descripción
Sumario:Bimodal nanoprobes comprising both magnetic and optical functionalities have been prepared via a sequential two-step process. Firstly, magnetite nanoparticles (MNPs) with well-defined cubic shape and an average dimension of 80 nm were produced by hydrolysis of iron sulfate and were then surface modified with silica shells by using the sol-gel method. The Fe(3)O(4)@SiO(2) particles were then functionalized with the fluorophore, fluorescein isothiocyanate (FITC), mediated by assembled shells of the cationic polyelectrolyte, polyethyleneimine (PEI). The Fe(3)O(4) functionalized particles were then preliminary evaluated as fluorescent and magnetic probes by performing studies in which neuroblast cells have been contacted with these nanomaterials.

Ejemplares similares