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Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma

OBJECTIVE: To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. MATERIALS AND METHODS: This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contr...

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Autores principales: Park, Ji Eun, Ryu, Kyoung Hwa, Kim, Ho Sung, Kim, Hyo Won, Shim, Woo Hyun, Jung, Seung Chai, Choi, Choong Gon, Kim, Sang Joon, Kim, Jeong Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521835/
https://www.ncbi.nlm.nih.gov/pubmed/28732091
http://dx.doi.org/10.1371/journal.pone.0181933
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author Park, Ji Eun
Ryu, Kyoung Hwa
Kim, Ho Sung
Kim, Hyo Won
Shim, Woo Hyun
Jung, Seung Chai
Choi, Choong Gon
Kim, Sang Joon
Kim, Jeong Hoon
author_facet Park, Ji Eun
Ryu, Kyoung Hwa
Kim, Ho Sung
Kim, Hyo Won
Shim, Woo Hyun
Jung, Seung Chai
Choi, Choong Gon
Kim, Sang Joon
Kim, Jeong Hoon
author_sort Park, Ji Eun
collection PubMed
description OBJECTIVE: To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. MATERIALS AND METHODS: This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contrast-enhanced MR imaging after concurrent chemoradiation therapy. Two independent readers categorized the shape and perfusion state of SCWEs as nodular or non-nodular and as having positive or negative perfusion compared with the contralateral grey matter on arterial spin labeling (ASL). The perfusion fraction on ASL within the contrast-enhancing lesion was calculated. The independent predictability of TTP was analyzed using the Kaplan-Meier method and Cox proportional hazards modelling. RESULTS: The perfusion fraction was higher in the non-progression group, significantly for reader 2 (P = 0.03) and borderline significantly for reader 1 (P = 0.08). A positive perfusion state and (P = 0.02) a higher perfusion fraction of the SCWE were found to become an independent predictor of longer TTP (P = 0.001 for reader 1 and P < 0.001 for reader 2). The contrast enhancement pattern did not become a TTP predictor. CONCLUSION: Assessment of perfusion in early post-treatment MR imaging can stratify TTP in patients with glioblastoma for adjuvant temozolomide therapy. Positive perfusion in SCWEs can become a predictor of a longer TTP.
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spelling pubmed-55218352017-08-07 Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma Park, Ji Eun Ryu, Kyoung Hwa Kim, Ho Sung Kim, Hyo Won Shim, Woo Hyun Jung, Seung Chai Choi, Choong Gon Kim, Sang Joon Kim, Jeong Hoon PLoS One Research Article OBJECTIVE: To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. MATERIALS AND METHODS: This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contrast-enhanced MR imaging after concurrent chemoradiation therapy. Two independent readers categorized the shape and perfusion state of SCWEs as nodular or non-nodular and as having positive or negative perfusion compared with the contralateral grey matter on arterial spin labeling (ASL). The perfusion fraction on ASL within the contrast-enhancing lesion was calculated. The independent predictability of TTP was analyzed using the Kaplan-Meier method and Cox proportional hazards modelling. RESULTS: The perfusion fraction was higher in the non-progression group, significantly for reader 2 (P = 0.03) and borderline significantly for reader 1 (P = 0.08). A positive perfusion state and (P = 0.02) a higher perfusion fraction of the SCWE were found to become an independent predictor of longer TTP (P = 0.001 for reader 1 and P < 0.001 for reader 2). The contrast enhancement pattern did not become a TTP predictor. CONCLUSION: Assessment of perfusion in early post-treatment MR imaging can stratify TTP in patients with glioblastoma for adjuvant temozolomide therapy. Positive perfusion in SCWEs can become a predictor of a longer TTP. Public Library of Science 2017-07-21 /pmc/articles/PMC5521835/ /pubmed/28732091 http://dx.doi.org/10.1371/journal.pone.0181933 Text en © 2017 Park et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Park, Ji Eun
Ryu, Kyoung Hwa
Kim, Ho Sung
Kim, Hyo Won
Shim, Woo Hyun
Jung, Seung Chai
Choi, Choong Gon
Kim, Sang Joon
Kim, Jeong Hoon
Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma
title Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma
title_full Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma
title_fullStr Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma
title_full_unstemmed Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma
title_short Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma
title_sort perfusion of surgical cavity wall enhancement in early post-treatment mr imaging may stratify the time-to-progression in glioblastoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521835/
https://www.ncbi.nlm.nih.gov/pubmed/28732091
http://dx.doi.org/10.1371/journal.pone.0181933
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