Cargando…
Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma
OBJECTIVE: To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. MATERIALS AND METHODS: This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contr...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521835/ https://www.ncbi.nlm.nih.gov/pubmed/28732091 http://dx.doi.org/10.1371/journal.pone.0181933 |
_version_ | 1783252045899235328 |
---|---|
author | Park, Ji Eun Ryu, Kyoung Hwa Kim, Ho Sung Kim, Hyo Won Shim, Woo Hyun Jung, Seung Chai Choi, Choong Gon Kim, Sang Joon Kim, Jeong Hoon |
author_facet | Park, Ji Eun Ryu, Kyoung Hwa Kim, Ho Sung Kim, Hyo Won Shim, Woo Hyun Jung, Seung Chai Choi, Choong Gon Kim, Sang Joon Kim, Jeong Hoon |
author_sort | Park, Ji Eun |
collection | PubMed |
description | OBJECTIVE: To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. MATERIALS AND METHODS: This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contrast-enhanced MR imaging after concurrent chemoradiation therapy. Two independent readers categorized the shape and perfusion state of SCWEs as nodular or non-nodular and as having positive or negative perfusion compared with the contralateral grey matter on arterial spin labeling (ASL). The perfusion fraction on ASL within the contrast-enhancing lesion was calculated. The independent predictability of TTP was analyzed using the Kaplan-Meier method and Cox proportional hazards modelling. RESULTS: The perfusion fraction was higher in the non-progression group, significantly for reader 2 (P = 0.03) and borderline significantly for reader 1 (P = 0.08). A positive perfusion state and (P = 0.02) a higher perfusion fraction of the SCWE were found to become an independent predictor of longer TTP (P = 0.001 for reader 1 and P < 0.001 for reader 2). The contrast enhancement pattern did not become a TTP predictor. CONCLUSION: Assessment of perfusion in early post-treatment MR imaging can stratify TTP in patients with glioblastoma for adjuvant temozolomide therapy. Positive perfusion in SCWEs can become a predictor of a longer TTP. |
format | Online Article Text |
id | pubmed-5521835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55218352017-08-07 Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma Park, Ji Eun Ryu, Kyoung Hwa Kim, Ho Sung Kim, Hyo Won Shim, Woo Hyun Jung, Seung Chai Choi, Choong Gon Kim, Sang Joon Kim, Jeong Hoon PLoS One Research Article OBJECTIVE: To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. MATERIALS AND METHODS: This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contrast-enhanced MR imaging after concurrent chemoradiation therapy. Two independent readers categorized the shape and perfusion state of SCWEs as nodular or non-nodular and as having positive or negative perfusion compared with the contralateral grey matter on arterial spin labeling (ASL). The perfusion fraction on ASL within the contrast-enhancing lesion was calculated. The independent predictability of TTP was analyzed using the Kaplan-Meier method and Cox proportional hazards modelling. RESULTS: The perfusion fraction was higher in the non-progression group, significantly for reader 2 (P = 0.03) and borderline significantly for reader 1 (P = 0.08). A positive perfusion state and (P = 0.02) a higher perfusion fraction of the SCWE were found to become an independent predictor of longer TTP (P = 0.001 for reader 1 and P < 0.001 for reader 2). The contrast enhancement pattern did not become a TTP predictor. CONCLUSION: Assessment of perfusion in early post-treatment MR imaging can stratify TTP in patients with glioblastoma for adjuvant temozolomide therapy. Positive perfusion in SCWEs can become a predictor of a longer TTP. Public Library of Science 2017-07-21 /pmc/articles/PMC5521835/ /pubmed/28732091 http://dx.doi.org/10.1371/journal.pone.0181933 Text en © 2017 Park et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Park, Ji Eun Ryu, Kyoung Hwa Kim, Ho Sung Kim, Hyo Won Shim, Woo Hyun Jung, Seung Chai Choi, Choong Gon Kim, Sang Joon Kim, Jeong Hoon Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma |
title | Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma |
title_full | Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma |
title_fullStr | Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma |
title_full_unstemmed | Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma |
title_short | Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma |
title_sort | perfusion of surgical cavity wall enhancement in early post-treatment mr imaging may stratify the time-to-progression in glioblastoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521835/ https://www.ncbi.nlm.nih.gov/pubmed/28732091 http://dx.doi.org/10.1371/journal.pone.0181933 |
work_keys_str_mv | AT parkjieun perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT ryukyounghwa perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT kimhosung perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT kimhyowon perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT shimwoohyun perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT jungseungchai perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT choichoonggon perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT kimsangjoon perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma AT kimjeonghoon perfusionofsurgicalcavitywallenhancementinearlyposttreatmentmrimagingmaystratifythetimetoprogressioninglioblastoma |