Neprilysin Is Required for Angiotensin-(1–7)’s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1–2)

Recent work has renewed interest in therapies targeting the renin-angiotensin system (RAS) to improve β-cell function in type 2 diabetes. Studies show that generation of angiotensin-(1–7) by ACE2 and its binding to the Mas receptor (MasR) improves glucose homeostasis, partly by enhancing glucose-sti...

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Detalles Bibliográficos
Autores principales: Brar, Gurkirat S., Barrow, Breanne M., Watson, Matthew, Griesbach, Ryan, Choung, Edwina, Welch, Andrew, Ruzsicska, Bela, Raleigh, Daniel P., Zraika, Sakeneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521860/
https://www.ncbi.nlm.nih.gov/pubmed/28559246
http://dx.doi.org/10.2337/db16-1318

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