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Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass

Regulation of glucose homeostasis by insulin depends on β-cell growth and function. Nutrients and growth factor stimuli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two complexes, mTORC1 and mTORC2. To understand the functional relevance of mTOR enzyma...

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Detalles Bibliográficos
Autores principales:	Alejandro, Emilyn U., Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Wasan, Michelle Ann, Elghazi, Lynda, Vadrevu, Suryakiran, Satin, Leslie, Bernal-Mizrachi, Ernesto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2017
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521866/ https://www.ncbi.nlm.nih.gov/pubmed/28546423 http://dx.doi.org/10.2337/db16-1349

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