A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first-phase insulin secretion, as measured by intraveno...

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Detalles Bibliográficos
Autores principales: Wood, Andrew R., Jonsson, Anna, Jackson, Anne U., Wang, Nan, van Leewen, Nienke, Palmer, Nicholette D., Kobes, Sayuko, Deelen, Joris, Boquete-Vilarino, Lorena, Paananen, Jussi, Stančáková, Alena, Boomsma, Dorret I., de Geus, Eco J.C., Eekhoff, Elisabeth M.W., Fritsche, Andreas, Kramer, Mark, Nijpels, Giel, Simonis-Bik, Annemarie, van Haeften, Timon W., Mahajan, Anubha, Boehnke, Michael, Bergman, Richard N., Tuomilehto, Jaakko, Collins, Francis S., Mohlke, Karen L., Banasik, Karina, Groves, Christopher J., McCarthy, Mark I., Pearson, Ewan R., Natali, Andrea, Mari, Andrea, Buchanan, Thomas A., Taylor, Kent D., Xiang, Anny H., Gjesing, Anette P., Grarup, Niels, Eiberg, Hans, Pedersen, Oluf, Chen, Yii-Derr, Laakso, Markku, Norris, Jill M., Smith, Ulf, Wagenknecht, Lynne E., Baier, Leslie, Bowden, Donald W., Hansen, Torben, Walker, Mark, Watanabe, Richard M., ‘t Hart, Leen M., Hanson, Robert L., Frayling, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521867/
https://www.ncbi.nlm.nih.gov/pubmed/28490609
http://dx.doi.org/10.2337/db16-1452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521867/
https://www.ncbi.nlm.nih.gov/pubmed/28490609
http://dx.doi.org/10.2337/db16-1452

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